PMID- 26131199
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150701
LR  - 20201001
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 4
DP  - 2015
TI  - Clinicopathologic significance and survival of TIP30 expression in laryngeal 
      squamous cell carcinoma.
PG  - 6024-31
AB  - BACKGROUND: The expression and clinical significance of TIP30 and p53 in 
      laryngeal squamous cell carcinoma (LSCC) have not been investigated. METHOD: We 
      determined immunohistochemically the expression of TIP30 and p53 in surgical 
      specimens from 105 patients with LSCC. Survivals were estimated using the 
      Kaplan-Meier method. RESULTS: TIP30 protein expression in LSCC patients was 
      significantly less in tumor tissues than that of adjacent normal tissues (46.7% 
      vs. 79.0%), while p53 protein expression was significantly increased in LSCC 
      (15.2% vs. 63.8%) compared with adjacent normal tissues. The TIP30 expression 
      levels were also significantly correlated with tumor stage, differentiation, and 
      the presence of lymph nodes. The expression of TIP30 was significantly negatively 
      correlated with that of p53 (r = -0.249, P = 0.010). LSCC patients with lower 
      expression level of TIP30 had a significantly higher recurrence and worse overall 
      survival than those with elevated TIP30 expression (P = 0.014 and P = 0.040, 
      respectively). Furthermore, multivariable analysis found that patients with high 
      expression of TIP30 had a greater than approximately 2.2-fold increased risk for 
      death overall or recurrence than those with low expression of TIP30, supporting 
      that down-regulation of TIP30 expression in tumors may involve in development and 
      progression and predict poor prognosis of patients with LSCC. CONCLUSION: Our 
      results may suggest that down-expression of TIP30 is closely related to 
      carcinogenesis, progression, biological behavior, and prognosis of LSCC.
FAU - Chen, Jianqiu
AU  - Chen J
AD  - Department of Otolaryngology Head and Neck Surgery, Jinan General Hospital of PLA 
      Jinan 250031, Shandong Province, China.
FAU - Zhu, Chunsheng
AU  - Zhu C
AD  - Department of Otolaryngology Head and Neck Surgery, Jinan General Hospital of PLA 
      Jinan 250031, Shandong Province, China.
FAU - Zhu, Minhui
AU  - Zhu M
AD  - Department of Otolaryngology Head and Neck Surgery, Changhai Hospital of The 
      Second Military Medical University Shanghai 200433, China.
FAU - Geng, Ming
AU  - Geng M
AD  - Department of Pathology, Jinan General Hospital of PLA Jinan 250031, Shandong 
      Province, China.
FAU - Tian, Yongsheng
AU  - Tian Y
AD  - Department of Otolaryngology Head and Neck Surgery, Aerospace Center Hospital of 
      Beijing University Beijing 100049, China.
FAU - Li, Guojun
AU  - Li G
AD  - Department of Head and Neck Surgery, U.T. M.D. Anderson Cancer Center Houston, TX 
      77030, USA.
FAU - Zheng, Hongliang
AU  - Zheng H
AD  - Department of Otolaryngology Head and Neck Surgery, Changhai Hospital of The 
      Second Military Medical University Shanghai 200433, China.
LA  - eng
PT  - Journal Article
DEP - 20150415
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4484035
OTO - NOTNLM
OT  - Laryngeal squamous carcinoma
OT  - TIP30
OT  - p53
OT  - survival
EDAT- 2015/07/02 06:00
MHDA- 2015/07/02 06:01
PMCR- 2015/04/15
CRDT- 2015/07/02 06:00
PHST- 2015/01/15 00:00 [received]
PHST- 2015/03/24 00:00 [accepted]
PHST- 2015/07/02 06:00 [entrez]
PHST- 2015/07/02 06:00 [pubmed]
PHST- 2015/07/02 06:01 [medline]
PHST- 2015/04/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Apr 15;8(4):6024-31. eCollection 2015.