PMID- 26131224
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150701
LR  - 20200930
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 4
DP  - 2015
TI  - Peptic ulcer hemorrhage combined with acute gout: analyses of treatment in 136 
      cases.
PG  - 6193-9
AB  - This study aims to compare the safety and curative effect of celecoxib and 
      small-dose methylprednisolone sodium succinate in patients with peptic ulcer 
      hemorrhage combined with acute gout. In this randomized, controlled trial, a 
      total of 136 patients with peptic ulcer hemorrhage combined with acute gout were 
      divided into the celecoxib group or the small-dose methylprednisolone sodium 
      succinate group. These patients underwent gastroscopy hemostasis and proton pump 
      inhibitor (PPI) therapy. Moreover, for the treatment of gout, the patients were 
      administered either celecoxib or small-dose methylprednisolone sodium succinate. 
      Adverse reactions and the visual analogue scale (VAS) score were recorded for the 
      two groups. The difference in adverse reactions between the two groups was not 
      significant (chi(2) = 0.002, P = 0.967). The duration of evident pain relief after 
      the first dose of treatment showed a significant difference between the two 
      groups (t = 13.728, P < 0.01). The VAS scores before treatment were not 
      significantly different between the two groups (t = -1.786, P = 0.076). The VAS 
      scores at 6 h, 2 days, 4 days, 6 days, and 8 days after treatment were 
      significantly different between the two groups (t = 3.239, 6.586, 6.280, 3.737, 
      3.215; P = 0.002, 0.000, 0.000, 0.000, 0.002, respectively). In cases that 
      receive effective gastroscopy hemostasis and PPI therapy, small-dose 
      methylprednisolone sodium succinate exhibits a greater clinical curative effect 
      for peptic ulcer hemorrhage combined with acute gout as compared to celecoxib, 
      and is associated with greater safety.
FAU - Xu, Zhenglei
AU  - Xu Z
AD  - Department of Gastroenterology, Second Clinical Medical College of Jinan 
      University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, 
      China.
FAU - Zhang, Ru
AU  - Zhang R
AD  - Department of Gastroenterology, Second Clinical Medical College of Jinan 
      University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, 
      China.
FAU - Zhang, Dingguo
AU  - Zhang D
AD  - Department of Gastroenterology, Second Clinical Medical College of Jinan 
      University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, 
      China.
FAU - Yao, Jun
AU  - Yao J
AD  - Department of Gastroenterology, Second Clinical Medical College of Jinan 
      University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, 
      China.
FAU - Shi, Ruiyue
AU  - Shi R
AD  - Department of Gastroenterology, Second Clinical Medical College of Jinan 
      University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, 
      China.
FAU - Tang, Qinghong
AU  - Tang Q
AD  - Department of Gastroenterology, Second Clinical Medical College of Jinan 
      University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, 
      China.
FAU - Wang, Lisheng
AU  - Wang L
AD  - Department of Gastroenterology, Second Clinical Medical College of Jinan 
      University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20150415
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4483932
OTO - NOTNLM
OT  - Peptic ulcer
OT  - acute gout
OT  - hemorrhage
EDAT- 2015/07/02 06:00
MHDA- 2015/07/02 06:01
PMCR- 2015/04/15
CRDT- 2015/07/02 06:00
PHST- 2015/02/02 00:00 [received]
PHST- 2015/04/02 00:00 [accepted]
PHST- 2015/07/02 06:00 [entrez]
PHST- 2015/07/02 06:00 [pubmed]
PHST- 2015/07/02 06:01 [medline]
PHST- 2015/04/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Apr 15;8(4):6193-9. eCollection 2015.