PMID- 26131815
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 26
DP  - 2015 Jul
TI  - Investigation of Gastroduodenal Mucosal Injury in Japanese Asymptomatic 
      Antiplatelet Drug Users.
PG  - e1047
LID - 10.1097/MD.0000000000001047 [doi]
LID - e1047
AB  - Antiplatelet drugs are widely used for the prevention of cardiovascular disease 
      and cerebral vascular disorders. Although there have been several studies on 
      gastroduodenal mucosal injury with gastrointestinal (GI) symptoms such as GI 
      bleeding, in antiplatelet drug users (including low-dose aspirin (LDA)), there 
      have been few reports on the association between antiplatelet drug use and 
      gastroduodenal mucosal injury in asymptomatic antiplatelet drug users. This study 
      was a cross-sectional study elucidating the association between antiplatelet drug 
      use and gastroduodenal mucosal injury in asymptomatic antiplatelet drug 
      users.Subjects were 186 asymptomatic Japanese antiplatelet drug users who 
      underwent a regular health checkup. Subjects were divided into those with and 
      without gastroduodenal mucosal injury endoscopically, and the association between 
      gastroduodenal mucosal injury and other data in asymptomatic antiplatelet drug 
      users was investigated.The prevalence of males and drinkers were significantly 
      higher in subjects with gastroduodenal mucosal injury than in those without. In 
      addition, the prevalence of proton pump inhibitor (PPI) users was significantly 
      lower in subjects with gastroduodenal mucosal injury than in subjects without 
      gastroduodenal mucosal injury. Logistic regression analysis showed PPI (odds 
      ratios: 0.116; 95% confidence intervals: 0.021-0.638; P < 0.05) was a significant 
      predictor of a decreased prevalence of gastroduodenal mucosal injury and 
      closed-type (C-type) atrophy (3.172; 1.322-7.609; P < 0.01) was a significant 
      predictor of an increased prevalence of severe gastroduodenal mucosal injury in 
      asymptomatic antiplatelet drug users.Gender and lifestyle, such as drinking, may 
      have an impact on risk of gastroduodenal mucosal injury in asymptomatic subjects 
      taking antiplatelet drugs. Although PPI is a significant predictor of a decreased 
      prevalence of gastroduodenal mucosal injury, including in asymptomatic 
      antiplatelet drug users, status of gastric atrophy should also be considered 
      against severe gastroduodenal mucosal injury.
FAU - Sogabe, Masahiro
AU  - Sogabe M
AD  - From the Department of General Medicine and Community Health Science, Institute 
      of Health, Biosciences, Tokushima University Graduate School (MS, TO); Department 
      of Gastroenterology and Oncology, Institute of Health Biosciences, Tokushima 
      University Graduate School, Tokushima (MS, TO, YF, YM, YT, TK, KO, NM, TT); 
      Department of Gastroenterology, Kagawa Prefectural Cancer Detection Center, 
      Takamatsu, Japan (MS); Department of Internal Medicine, Tsurugi Municipal Handa 
      Hospital, Tokushima, Japan (MN).
FAU - Okahisa, Toshiya
AU  - Okahisa T
FAU - Nakasono, Masahiko
AU  - Nakasono M
FAU - Fujino, Yasuteru
AU  - Fujino Y
FAU - Mitsui, Yasuhiro
AU  - Mitsui Y
FAU - Takaoka, Yoshihumi
AU  - Takaoka Y
FAU - Kimura, Tetsuo
AU  - Kimura T
FAU - Okamoto, Koichi
AU  - Okamoto K
FAU - Muguruma, Naoki
AU  - Muguruma N
FAU - Takayama, Tetsuji
AU  - Takayama T
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Endoscopy, Gastrointestinal
MH  - Female
MH  - Gastric Mucosa/*injuries
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation Inhibitors/*adverse effects
MH  - Retrospective Studies
MH  - Stomach Diseases/*chemically induced/diagnosis
MH  - Young Adult
PMC - PMC4504548
COIS- The authors report no conflicts of interest.
EDAT- 2015/07/02 06:00
MHDA- 2015/09/22 06:00
PMCR- 2015/07/02
CRDT- 2015/07/02 06:00
PHST- 2015/07/02 06:00 [entrez]
PHST- 2015/07/02 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
PHST- 2015/07/02 00:00 [pmc-release]
AID - 00005792-201507010-00032 [pii]
AID - 10.1097/MD.0000000000001047 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Jul;94(26):e1047. doi: 10.1097/MD.0000000000001047.