PMID- 26132167
OWN - NLM
STAT- MEDLINE
DCOM- 20160406
LR  - 20200306
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 7
DP  - 2015
TI  - Dosimetric Evaluation of a Simple Planning Technique for Improving 
      Intensity-Modulated Radiotherapy for Nasopharyngeal Cancer.
PG  - e0129461
LID - 10.1371/journal.pone.0129461 [doi]
LID - e0129461
AB  - PURPOSE: To evaluate the dosimetric outcomes of a simple planning technique for 
      improving intensity-modulated radiotherapy (IMRT) for nasopharyngeal cancer 
      (NPC). METHODS: For 39 NPC cases, generally acceptable original plans were 
      generated and were improved by the two planning techniques, respectively: (1) a 
      basal-dose-compensation (BDC) technique, in which the treatment plans were 
      re-optimized based on the original plans; (2) a local-dose-control (LDC) 
      technique, in which the original plans were re-optimized with constraints for hot 
      and cold spots. The BDC, original, and LDC plans were then compared regarding 
      homogeneity index (HI) and conformity index (CI) of planning target volumes 
      (PTVs), organ-at-risk (OAR) sparing and monitor units (MUs) per fraction. The 
      whole planning times were also compared between the BDC and LDC plans. RESULTS: 
      The BDC plans had superior HIs / CIs, by 13-24% / 3-243%, respectively, over the 
      original plans. Compared to the LDC plans, the BDC plans provided better HIs only 
      for PTVnx (the PTV of nasopharyngeal primary tumor) by 11% and better CIs for all 
      PTVs by 2-134%. The BDC technique spared most OARs, by 1-9%. The average MUs of 
      the BDC, original, and LDC plans were 2149, 2068 and 2179, respectively. The 
      average whole planning times were 48 and 69 minutes for the BDC and LDC plans, 
      respectively. CONCLUSIONS: For the IMRT of nasopharyngeal cancer, the BDC 
      planning technique can improve target dose homogeneity, conformity and OAR 
      sparing, with better planning efficiency.
FAU - Lu, Jia-Yang
AU  - Lu JY
AD  - Department of Radiation Oncology, Cancer Hospital of Shantou University Medical 
      College, Shantou, Guangdong, China.
FAU - Cheung, Michael Lok-Man
AU  - Cheung ML
AD  - Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong, 
      China.
FAU - Li, Mei
AU  - Li M
AD  - Department of Radiation Oncology, Cancer Hospital of Shantou University Medical 
      College, Shantou, Guangdong, China.
FAU - Huang, Bao-Tian
AU  - Huang BT
AD  - Department of Radiation Oncology, Cancer Hospital of Shantou University Medical 
      College, Shantou, Guangdong, China.
FAU - Xie, Wen-Jia
AU  - Xie WJ
AD  - Department of Radiation Oncology, Cancer Hospital of Shantou University Medical 
      College, Shantou, Guangdong, China.
FAU - Xie, Liang-Xi
AU  - Xie LX
AD  - Department of Radiation Oncology, Cancer Hospital of Shantou University Medical 
      College, Shantou, Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150701
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/diagnosis/*radiotherapy
MH  - Planning Techniques
MH  - Radiometry
MH  - Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - *Radiotherapy, Intensity-Modulated/methods
MH  - Tomography, X-Ray Computed
MH  - Young Adult
PMC - PMC4488438
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/07/02 06:00
MHDA- 2016/04/07 06:00
PMCR- 2015/07/01
CRDT- 2015/07/02 06:00
PHST- 2015/02/04 00:00 [received]
PHST- 2015/05/09 00:00 [accepted]
PHST- 2015/07/02 06:00 [entrez]
PHST- 2015/07/02 06:00 [pubmed]
PHST- 2016/04/07 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - PONE-D-15-05218 [pii]
AID - 10.1371/journal.pone.0129461 [doi]
PST - epublish
SO  - PLoS One. 2015 Jul 1;10(7):e0129461. doi: 10.1371/journal.pone.0129461. 
      eCollection 2015.