PMID- 26133818
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20190318
IS  - 1007-3418 (Print)
IS  - 1007-3418 (Linking)
VI  - 23
IP  - 4
DP  - 2015 Apr
TI  - [Correlation between polymorphisms in the human leukocyte antigen-DQB1 alleles 
      and hepatitis B with primary hepatocellular carcinoma].
PG  - 270-4
LID - cma.j.issn.1007-3418.2015.04 [pii]
LID - 10.3760/cma.j.issn.1007-3418.2015.04.008 [doi]
AB  - OBJECTIVE: To investigate the correlation between polymorphisms in human 
      leukocyte antigen (HLA)-DQB 1 and primary liver cancer (PLC) with hepatitis B 
      virus (HBV) and to search for susceptibility and resistance genes related to PLC 
      with HBV. METHODS: One hundred and eighteen patients with HBV-related liver 
      cancer were enrolled from the First Hospital of Shanxi Medical University. 
      Patients were stratified by family history of hepatitis B (39 with; 79 without) 
      and HBV DNA positivity (60 positive, >/=1*10(3) IU/mL; 58 negative, <1*10(3) 
      IU/mL). The HLA-DQB 1 genotype was determined by PCR and direct nucleotide 
      sequence analysis genotyping. Allele frequencies were calculated by the direct 
      counting method. Betweengroup comparisons were carried out with the Chi-square 
      test or Mann-Whitney U test. RESULTS: The allele frequencies of HLA-DQBl*0202 and 
      HLA-DQBl*0301 were significantly higher in patients with hepatocellular carcinoma 
      (HCC) than the control group (1 1.8% and 29.3% vs. 7.6% and 21.1%; U=2.43 and 
      3.09, P<0.05, RR=1.581 and 1.477). The allele frequencies of HLA-DQB1*0202 and 
      HLADQB 1*0301 were significantly higher in patients with HCC and familial history 
      of hepatitis B than in the normal population (14.1% and 29.5% vs. 7.6% and 21.1%; 
      U=3.76 and 3.16, P less than 0.05, RR=1.928 and 1.495). The allele frequency of 
      HLA-DQB 1*0301 was significantly higher in the HBV DNA positive group than in the 
      HBV DNA negative group (35.0% vs. 23.3%; x2=5.543, P less than 0.05, RR=1.775), 
      while the frequency of HLA-DQB1*0302 was significantly lower in the HBV DNA 
      positive group than in the HBV DNA negative group (10.9% vs. 14.7%; x2=4.604, 
      P<0.05, RR=0.229). CONCLUSIONS: The HLA-DQB 1 *0202 and HLA-DQB 1*0301 alleles 
      may represent susceptibility for PLC with hepatitis B as well as for familial 
      hepatitis B liver cancer. The HLA-DQB 1*0301 allele may support replication of 
      HBV DNA, facilitating progression to liver cancer. The HLA-DQB1*0302 allele may 
      inhibit replication of HBV DNA and reduce the incidence of liver cancer.
FAU - Li, Qiongjie
AU  - Li Q
AD  - Department of Infectious Diseases, First Hospital of Shanxi Medical University, 
      Taiyuan 030001, China.
FAU - Li, Xinxin
AU  - Li X
FAU - Zhang, Liaoyun
AU  - Zhang L
FAU - Zhao, Longfeng
AU  - Zhao L
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Gan Zang Bing Za Zhi
JT  - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of 
      hepatology
JID - 9710009
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - *Alleles
MH  - *Carcinoma, Hepatocellular
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DQ beta-Chains
MH  - Hepatitis B
MH  - Hepatitis B virus
MH  - Hepatitis B, Chronic
MH  - Humans
MH  - *Liver Neoplasms
MH  - *Polymorphism, Genetic
EDAT- 2015/07/03 06:00
MHDA- 2016/02/03 06:00
CRDT- 2015/07/03 06:00
PHST- 2015/07/03 06:00 [entrez]
PHST- 2015/07/03 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
AID - cma.j.issn.1007-3418.2015.04 [pii]
AID - 10.3760/cma.j.issn.1007-3418.2015.04.008 [doi]
PST - ppublish
SO  - Zhonghua Gan Zang Bing Za Zhi. 2015 Apr;23(4):270-4. doi: 
      10.3760/cma.j.issn.1007-3418.2015.04.008.