PMID- 26134740
OWN - NLM
STAT- MEDLINE
DCOM- 20160701
LR  - 20150916
IS  - 1464-5157 (Electronic)
IS  - 0265-6736 (Linking)
VI  - 31
IP  - 6
DP  - 2015
TI  - Accurate 3D temperature dosimetry during hyperthermia therapy by combining 
      invasive measurements and patient-specific simulations.
PG  - 686-92
LID - 10.3109/02656736.2015.1052855 [doi]
AB  - PURPOSE: Dosimetry during deep local hyperthermia treatments in the head and neck 
      currently relies on a limited number of invasively placed temperature sensors. 
      The purpose of this study was to assess the feasibility of 3D dosimetry based on 
      patient-specific temperature simulations and sensory feedback. MATERIALS AND 
      METHODS: The study includes 10 patients with invasive thermometry applied in at 
      least two treatments. Based on their invasive thermometry, we optimised 
      patient-group thermal conductivity and perfusion values for muscle, fat and 
      tumour using a 'leave-one-out' approach. Next, we compared the accuracy of the 
      predicted temperature (DeltaT) and the hyperthermia treatment quality (DeltaT50) of the 
      optimisations based on the patient-group properties to those based on 
      patient-specific properties, which were optimised using previous treatment 
      measurements. As a robustness check, and to enable comparisons with previous 
      studies, we optimised the parameters not only for an applicator efficiency factor 
      of 40%, but also for 100% efficiency. RESULTS: The accuracy of the predicted 
      temperature (DeltaT) improved significantly using patient-specific tissue properties, 
      i.e. 1.0  degrees C (inter-quartile range (IQR) 0.8  degrees C) compared to 1.3  degrees C (IQR 0.7  degrees C) 
      for patient-group averaged tissue properties for 100% applicator efficiency. A 
      similar accuracy was found for optimisations using an applicator efficiency 
      factor of 40%, indicating the robustness of the optimisation method. Moreover, in 
      eight patients with repeated measurements in the target region, DeltaT50 
      significantly improved, i.e. DeltaT50 reduced from 0.9  degrees C (IQR 0.8  degrees C) to 0.4  degrees C (IQR 
      0.5  degrees C) using an applicator efficiency factor of 40%. CONCLUSION: This study 
      shows that patient-specific temperature simulations combined with tissue property 
      reconstruction from sensory data provides accurate minimally invasive 3D 
      dosimetry during hyperthermia treatments: T50 in sessions without invasive 
      measurements can be predicted with a median accuracy of 0.4  degrees C.
FAU - Verhaart, Rene F
AU  - Verhaart RF
AD  - a Hyperthermia Unit, Department of Radiation Oncology, Cancer Institute , Erasmus 
      Medical Centre , Rotterdam , and.
FAU - Verduijn, Gerda M
AU  - Verduijn GM
AD  - a Hyperthermia Unit, Department of Radiation Oncology, Cancer Institute , Erasmus 
      Medical Centre , Rotterdam , and.
FAU - Fortunati, Valerio
AU  - Fortunati V
AD  - b Departments of Medical Informatics and Radiology , Biomedical Imaging Group 
      Rotterdam, Erasmus Medical Centre , Rotterdam , the Netherlands.
FAU - Rijnen, Zef
AU  - Rijnen Z
AD  - a Hyperthermia Unit, Department of Radiation Oncology, Cancer Institute , Erasmus 
      Medical Centre , Rotterdam , and.
FAU - van Walsum, Theo
AU  - van Walsum T
AD  - b Departments of Medical Informatics and Radiology , Biomedical Imaging Group 
      Rotterdam, Erasmus Medical Centre , Rotterdam , the Netherlands.
FAU - Veenland, Jifke F
AU  - Veenland JF
AD  - b Departments of Medical Informatics and Radiology , Biomedical Imaging Group 
      Rotterdam, Erasmus Medical Centre , Rotterdam , the Netherlands.
FAU - Paulides, Margarethus M
AU  - Paulides MM
AD  - a Hyperthermia Unit, Department of Radiation Oncology, Cancer Institute , Erasmus 
      Medical Centre , Rotterdam , and.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150701
PL  - England
TA  - Int J Hyperthermia
JT  - International journal of hyperthermia : the official journal of European Society 
      for Hyperthermic Oncology, North American Hyperthermia Group
JID - 8508395
SB  - IM
MH  - Head and Neck Neoplasms/*therapy
MH  - Humans
MH  - *Hyperthermia, Induced
MH  - *Patient-Specific Modeling
MH  - Temperature
MH  - Thermometry
OTO - NOTNLM
OT  - 3D dosimetry
OT  - Pennes' bioheat equation
OT  - mild deep local hyperthermia
OT  - patient-specific
OT  - thermal tissue property optimisation
EDAT- 2015/07/03 06:00
MHDA- 2016/07/02 06:00
CRDT- 2015/07/03 06:00
PHST- 2015/07/03 06:00 [entrez]
PHST- 2015/07/03 06:00 [pubmed]
PHST- 2016/07/02 06:00 [medline]
AID - 10.3109/02656736.2015.1052855 [doi]
PST - ppublish
SO  - Int J Hyperthermia. 2015;31(6):686-92. doi: 10.3109/02656736.2015.1052855. Epub 
      2015 Jul 1.