PMID- 26134755
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20170512
IS  - 2154-4700 (Electronic)
IS  - 1933-8244 (Linking)
VI  - 71
IP  - 5
DP  - 2016 Sep 2
TI  - Occupational sensitization to lactase in the dietary supplement industry.
PG  - 259-267
AB  - Aerogen lactase exposure carries a risk for the development of allergic asthma 
      and rhinitis; only a few occupationally affected patients have been reported. The 
      authors report the results of allergy testing with employees of a lactase tablets 
      manufacturing plant. The survey involved 13 workers, including a questionnaire, 
      spirometry, basophil activation test (BAT), and skin prick tests (SPTs) with 
      lactase and a panel of common aeroallergens. Furthermore, lactase-specific 
      immunoglobulin E (IgE) antibodies were analyzed. Sensitization to lactase could 
      be proven for 9 workers by SPT and BAT; specific IgE antibodies could be detected 
      in serum samples of all sensitized. However, IgE levels >/=0.35 kU/L were only 
      found in 4 sera. These data confirm that occupational exposure to lactase can 
      induce IgE-mediated respiratory sensitization resulting in allergic diseases. 
      Protective measures should thus be obligatory when working with lactase.
FAU - Stocker, Benedikt
AU  - Stocker B
AD  - a Department of Dermatology , University Hospital Munster , Munster , Germany.
FAU - Grundmann, Sonja
AU  - Grundmann S
AD  - a Department of Dermatology , University Hospital Munster , Munster , Germany.
FAU - Mosters, Pia
AU  - Mosters P
AD  - a Department of Dermatology , University Hospital Munster , Munster , Germany.
FAU - Nitzsche, Paul
AU  - Nitzsche P
AD  - b Werkarztzentrum Rietberg e.V. , Rietberg , Germany.
FAU - Brehler, Randolf
AU  - Brehler R
AD  - a Department of Dermatology , University Hospital Munster , Munster , Germany.
LA  - eng
PT  - Journal Article
DEP - 20150702
PL  - United States
TA  - Arch Environ Occup Health
JT  - Archives of environmental & occupational health
JID - 101282564
RN  - 0 (Allergens)
RN  - 0 (Tablets)
RN  - EC 3.2.1.108 (Lactase)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Dietary Supplements
MH  - Female
MH  - *Food-Processing Industry
MH  - Humans
MH  - Hypersensitivity/*etiology
MH  - Lactase/*immunology
MH  - Middle Aged
MH  - *Occupational Exposure
MH  - Tablets
OTO - NOTNLM
OT  - Aspergillus oryzae
OT  - enzyme allergy
OT  - inhalative allergy
OT  - lactase
OT  - occupational
EDAT- 2015/07/03 06:00
MHDA- 2017/05/13 06:00
CRDT- 2015/07/03 06:00
PHST- 2015/07/03 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
PHST- 2015/07/03 06:00 [entrez]
AID - 10.1080/19338244.2015.1066294 [doi]
PST - ppublish
SO  - Arch Environ Occup Health. 2016 Sep 2;71(5):259-267. doi: 
      10.1080/19338244.2015.1066294. Epub 2015 Jul 2.