PMID- 26136653
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150703
LR  - 20200930
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 9
DP  - 2015
TI  - Dopamine in socioecological and evolutionary perspectives: implications for 
      psychiatric disorders.
PG  - 219
LID - 10.3389/fnins.2015.00219 [doi]
LID - 219
AB  - Dopamine (DA) transmission in brain areas such as the prefrontal cortex (PFC) and 
      nucleus accumbens (NAcc) plays important roles in cognitive and affective 
      function. As such, DA deficits have been implicated in a number of psychiatric 
      disorders such as schizophrenia and attention deficit/hyperactivity disorder 
      (ADHD). Accumulating evidence suggests that DA is also involved in social 
      behavior of animals and humans. Although most animals organize and live in social 
      groups, how the DA system functions in such social groups of animals, and its 
      dysfunction causes compromises in the groups has remained less understood. Here 
      we propose that alterations of DA signaling and associated genetic variants and 
      behavioral phenotypes, which have been normally considered as "deficits" in 
      investigation at an individual level, may not necessarily yield disadvantages, 
      but even work advantageously, depending on social contexts in groups. This 
      hypothesis could provide a novel insight into our understanding of the biological 
      mechanisms of psychiatric disorders, and a potential explanation that 
      disadvantageous phenotypes associated with DA deficits in psychiatric disorders 
      have remained in humans through evolution.
FAU - Yamaguchi, Yoshie
AU  - Yamaguchi Y
AD  - Section of Cognition and Learning, Department of Cognitive Science, Primate 
      Research Institute, Kyoto University Inuyama, Japan.
FAU - Lee, Young-A
AU  - Lee YA
AD  - Department of Food Science and Nutrition, Catholic University of Daegu 
      Gyeongsan-Si, Korea.
FAU - Goto, Yukiori
AU  - Goto Y
AD  - Section of Cognition and Learning, Department of Cognitive Science, Primate 
      Research Institute, Kyoto University Inuyama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150616
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC4468839
OTO - NOTNLM
OT  - dopamine
OT  - evolution
OT  - genetic variants
OT  - primates
OT  - psychiatric disorder
OT  - social hierarchy
OT  - social interaction
EDAT- 2015/07/03 06:00
MHDA- 2015/07/03 06:01
PMCR- 2015/01/01
CRDT- 2015/07/03 06:00
PHST- 2015/04/15 00:00 [received]
PHST- 2015/06/01 00:00 [accepted]
PHST- 2015/07/03 06:00 [entrez]
PHST- 2015/07/03 06:00 [pubmed]
PHST- 2015/07/03 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2015.00219 [doi]
PST - epublish
SO  - Front Neurosci. 2015 Jun 16;9:219. doi: 10.3389/fnins.2015.00219. eCollection 
      2015.