PMID- 26136785
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150703
LR  - 20201001
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2015
DP  - 2015
TI  - Human Umbilical Cord Mesenchymal Stem Cells: A New Therapeutic Option for Tooth 
      Regeneration.
PG  - 549432
LID - 10.1155/2015/549432 [doi]
LID - 549432
AB  - Tooth regeneration is considered to be an optimistic approach to replace current 
      treatments for tooth loss. It is important to determine the most suitable seed 
      cells for tooth regeneration. Recently, human umbilical cord mesenchymal stem 
      cells (hUCMSCs) have been regarded as a promising candidate for tissue 
      regeneration. However, it has not been reported whether hUCMSCs can be employed 
      in tooth regeneration. Here, we report that hUCMSCs can be induced into 
      odontoblast-like cells in vitro and in vivo. Induced hUCMSCs expressed 
      dentin-related proteins including dentin sialoprotein (DSP) and dentin matrix 
      protein-1 (DMP-1), and their gene expression levels were similar to those in 
      native pulp tissue cells. Moreover, DSP- and DMP-1-positive calcifications were 
      observed after implantation of hUCMSCs in vivo. These findings reveal that 
      hUCMSCs have an odontogenic differentiation potency to differentiate to 
      odontoblast-like cells with characteristic deposition of dentin-like matrix in 
      vivo. This study clearly demonstrates hUCMSCs as an alternative therapeutic cell 
      source for tooth regeneration.
FAU - Chen, Yuanwei
AU  - Chen Y
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
FAU - Yu, Yongchun
AU  - Yu Y
AD  - Department of Stomatology, The First Affiliated Hospital of Guangzhou Medical 
      College, Guangzhou 510120, China.
FAU - Chen, Lin
AU  - Chen L
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
FAU - Ye, Lanfeng
AU  - Ye L
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
FAU - Cui, Junhui
AU  - Cui J
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
FAU - Sun, Quan
AU  - Sun Q
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
FAU - Li, Kaide
AU  - Li K
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
FAU - Li, Zhiyong
AU  - Li Z
AD  - Department of Oral & Maxillofacial Surgery, The First Affiliated Hospital, 
      College of Medicine, Zhejiang University, Hangzhou 310003, China.
FAU - Liu, Lei
AU  - Liu L
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
LA  - eng
PT  - Journal Article
DEP - 20150602
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC4468342
EDAT- 2015/07/03 06:00
MHDA- 2015/07/03 06:01
PMCR- 2015/06/02
CRDT- 2015/07/03 06:00
PHST- 2014/12/14 00:00 [received]
PHST- 2015/01/19 00:00 [accepted]
PHST- 2015/07/03 06:00 [entrez]
PHST- 2015/07/03 06:00 [pubmed]
PHST- 2015/07/03 06:01 [medline]
PHST- 2015/06/02 00:00 [pmc-release]
AID - 10.1155/2015/549432 [doi]
PST - ppublish
SO  - Stem Cells Int. 2015;2015:549432. doi: 10.1155/2015/549432. Epub 2015 Jun 2.