PMID- 26136901
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 9
IP  - 5
DP  - 2015 May
TI  - Association of BDNF and BCHE with Alzheimer's disease: Meta-analysis based on 56 
      genetic case-control studies of 12,563 cases and 12,622 controls.
PG  - 1831-1840
AB  - Alzheimer's disease (AD) is a common neurodegenerative disorder that can destroy 
      the memory of sufferers and lead to distress for the individual and society. 
      Brain-derived neurotrophic factor (BDNF) and butyrylcholinesterase (BCHE) are two 
      genes associated with beta-amyloid plaques and neurofibrillary tangles that are two 
      key factors in the pathophysiology of AD. The aim of the current meta-analysis 
      was to evaluate the association between BDNF Val66Met (rs6265), BDNF C270T 
      (rs2030324) and BCHE-K (rs1803274) polymorphisms and AD. A comprehensive 
      meta-analysis was performed using the online database PubMed without a time 
      limitation. A total of 56 articles evaluating 12,563 cases and 12,622 controls 
      were selected for the current meta-analysis. The results showed a moderate 
      association of the BDNF C270T polymorphism with the risk of AD in Asians under a 
      dominant model (P=0.03; odds ratio, 1.88; 95% confidence interval, 1.08-3.27). No 
      other significant association was found during the meta-analysis for the other 
      two polymorphisms (P>0.05). The current meta-analysis suggests that BDNF C270T is 
      a risk factor for AD in Asians. This meta-analysis has been, to the best of our 
      knowledge, the most comprehensive meta-analysis of BDNF Val66Met, BDNF C270T and 
      BCHE-K to date.
FAU - Ji, Huihui
AU  - Ji H
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Dai, Dongjun
AU  - Dai D
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Wang, Yunliang
AU  - Wang Y
AD  - Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255300, 
      P.R. China.
FAU - Jiang, Danjie
AU  - Jiang D
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Zhou, Xingyu
AU  - Zhou X
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Lin, Peipei
AU  - Lin P
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Ji, Xiaosui
AU  - Ji X
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Li, Jinfeng
AU  - Li J
AD  - Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255300, 
      P.R. China.
FAU - Zhang, Yuzheng
AU  - Zhang Y
AD  - Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255300, 
      P.R. China.
FAU - Yin, Honglei
AU  - Yin H
AD  - Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255300, 
      P.R. China.
FAU - Chen, Rongrong
AU  - Chen R
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Zhang, Lina
AU  - Zhang L
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Xu, Mingqing
AU  - Xu M
AD  - Bio-X Institutes, Key Laboratory for the Genetics of Developmental and 
      Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 
      Shanghai 20030, P.R. China.
FAU - Duan, Shiwei
AU  - Duan S
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
FAU - Wang, Qinwen
AU  - Wang Q
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20150303
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC4471730
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Asians
OT  - BCHE-K
OT  - BDNF C270T
OT  - BDNF Val66Met
OT  - meta-analysis
EDAT- 2015/07/03 06:00
MHDA- 2015/07/03 06:01
PMCR- 2015/03/03
CRDT- 2015/07/03 06:00
PHST- 2014/05/30 00:00 [received]
PHST- 2015/01/29 00:00 [accepted]
PHST- 2015/07/03 06:00 [entrez]
PHST- 2015/07/03 06:00 [pubmed]
PHST- 2015/07/03 06:01 [medline]
PHST- 2015/03/03 00:00 [pmc-release]
AID - ETM-0-0-2327 [pii]
AID - 10.3892/etm.2015.2327 [doi]
PST - ppublish
SO  - Exp Ther Med. 2015 May;9(5):1831-1840. doi: 10.3892/etm.2015.2327. Epub 2015 Mar 
      3.