PMID- 26138043 OWN - NLM STAT- MEDLINE DCOM- 20160727 LR - 20211122 IS - 1873-7560 (Electronic) IS - 0302-2838 (Linking) VI - 68 IP - 5 DP - 2015 Nov TI - Compliance Rates with the Prostate Cancer Research International Active Surveillance (PRIAS) Protocol and Disease Reclassification in Noncompliers. PG - 814-21 LID - S0302-2838(15)00515-1 [pii] LID - 10.1016/j.eururo.2015.06.012 [doi] AB - BACKGROUND: Men with prostate cancer on active surveillance (AS) are advised to follow strict follow-up schedules and switch to definitive treatment on risk reclassification. However, some men might not adhere to these strict protocols. OBJECTIVE: To determine the number of noncompliers and disease reclassification rates in men not complying with the follow-up protocol of the Prostate Cancer Research International Active Surveillance (PRIAS) study. DESIGN, SETTING, AND PARTICIPANTS: A total of 4547 men with low-risk prostate cancer were included and prospectively followed on AS. Men were regularly examined using prostate-specific antigen (PSA), digital rectal examination, and repeat biopsies, and were advised to switch to definitive treatment on disease reclassification (>cT2c, Gleason score > 3+3, >2 cores positive, or PSA doubling time [PSA-DT] 0-3 yr). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Rates of men not complying with follow-up visits or a recommendation to discontinue AS are reported. Biopsy outcome (Gleason >/=7 or >2 cores positive) was compared between compliers and noncompliers using Cox proportional hazards analysis. RESULTS AND LIMITATIONS: The compliance rate for PSA visits was 91%. By contrast, the compliance rate for standard repeat biopsies decreased over time (81%, 60%, 53%, and 33% at 1, 4, 7, and 10 yr after diagnosis, respectively). Yearly repeat biopsies in men with faster rising PSA (PSA-DT 3-10 yr) was low at <30%, although these men had higher upgrading rates at repeat biopsy (25-30% vs 16%). PSA-DT of 0-3 yr was the most common recommendation for discontinuation, but 71% continued on AS. Men with PSA-DT of 0-3 yr were at higher risk of upgrading on repeat biopsy (hazard ratio 2.02, 95% confidence interval 1.36-3.00) compared to men without fast rising PSA. CONCLUSION: Some men and their physicians do not comply with AS follow-up protocols. In particular, yearly repeat biopsies in men with fast rising PSA are often ignored, as is the recommendation to discontinue AS because of very fast rising PSA. Although these men are at greater risk of higher Gleason scores on repeat biopsy, the majority still exhibit favorable tumor characteristics. Fast rising PSA should therefore not trigger a recommendation to receive active treatment, but should rather serve as a criterion for stricter follow-up. In addition, we should aim to find ways of safely reducing the number of biopsies to increase adherence to AS protocols. PATIENT SUMMARY: We looked at compliance with an active surveillance protocol for low-risk prostate cancer in a large active surveillance study. We observed reluctance to undergo yearly biopsies because of fast rising prostate-specific antigen, despite a higher risk of disease progression. Further research should aim to safely reduce the number of repeat biopsies in men on active surveillance to increase protocol adherence. CI - Copyright (c) 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved. FAU - Bokhorst, Leonard P AU - Bokhorst LP AD - Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: l.bokhorst@erasmusmc.nl. FAU - Alberts, Arnout R AU - Alberts AR AD - Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands. FAU - Rannikko, Antti AU - Rannikko A AD - Department of Urology, Helsinki University Central Hospital, Helsinki, Finland. FAU - Valdagni, Riccardo AU - Valdagni R AD - Prostate Cancer Program and Radiation Oncology 1, Fondazione IRCSS Istituto Nazionale dei Tumori, Milan, Italy. FAU - Pickles, Tom AU - Pickles T AD - Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver, Canada. FAU - Kakehi, Yoshiyuki AU - Kakehi Y AD - Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan. FAU - Bangma, Chris H AU - Bangma CH AD - Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands. FAU - Roobol, Monique J AU - Roobol MJ AD - Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands. CN - PRIAS study group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150629 PL - Switzerland TA - Eur Urol JT - European urology JID - 7512719 RN - EC 3.4.21.- (KLK3 protein, human) RN - EC 3.4.21.- (Kallikreins) RN - EC 3.4.21.77 (Prostate-Specific Antigen) SB - IM CIN - Eur Urol. 2015 Nov;68(5):822-3. PMID: 26215607 MH - Aged MH - Biopsy MH - *Clinical Protocols MH - Digital Rectal Examination MH - Disease Progression MH - Humans MH - Kallikreins/blood MH - Male MH - Neoplasm Grading MH - Neoplasm Staging MH - Patient Compliance/*statistics & numerical data MH - Proportional Hazards Models MH - Prospective Studies MH - Prostate-Specific Antigen/blood MH - Prostatic Neoplasms MH - Risk MH - Watchful Waiting/*methods OTO - NOTNLM OT - Active surveillance OT - Compliance OT - Disease progression OT - Prostate biopsy OT - Prostate-specific antigen OT - Prostatic neoplasms EDAT- 2015/07/04 06:00 MHDA- 2016/07/28 06:00 CRDT- 2015/07/04 06:00 PHST- 2015/04/10 00:00 [received] PHST- 2015/06/14 00:00 [accepted] PHST- 2015/07/04 06:00 [entrez] PHST- 2015/07/04 06:00 [pubmed] PHST- 2016/07/28 06:00 [medline] AID - S0302-2838(15)00515-1 [pii] AID - 10.1016/j.eururo.2015.06.012 [doi] PST - ppublish SO - Eur Urol. 2015 Nov;68(5):814-21. doi: 10.1016/j.eururo.2015.06.012. Epub 2015 Jun 29.