PMID- 26138493
OWN - NLM
STAT- MEDLINE
DCOM- 20160322
LR  - 20150703
IS  - 1660-2862 (Electronic)
IS  - 1660-2854 (Linking)
VI  - 15
IP  - 3
DP  - 2015
TI  - Pharmacotherapy for Neurocognitive Disorders Based on the Hypothesis of 
      Endogenous Appearance of Anticholinergic Activity.
PG  - 157-61
LID - 10.1159/000381513 [doi]
AB  - We previously proposed the hypothesis of endogenous anticholinergic activity (AA) 
      in Alzheimer's disease (AD). According to this hypothesis, the downregulation of 
      acetylcholine seen in AD is associated with upregulation/hyperactivity of 
      N-methyl-D-aspartate receptor (NMDAR). The hyperactivation of NMDAR then induces 
      inflammation, which, in turn, causes AA to appear endogenously. Based on this 
      hypothesis, we commented that cholinesterase inhibitors (ChEIs) are 
      'preventative' therapy for AD and NMDAR antagonists are the true 'treatment' for 
      AD. We also noted that ChEIs, such as donepezil, could treat delirium. Moreover, 
      we proposed measuring serum anticholinergic activity in patients, particularly AD 
      patients, in out-of-hospital pharmacies to monitor the anticholinergic burden for 
      targeted treatment.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Hosoi, Misa
AU  - Hosoi M
AD  - Department of Psychiatry, Showa University Northern Yokohama Hospital, Yokohama, 
      Japan.
FAU - Hori, Koji
AU  - Hori K
FAU - Konishi, Kimiko
AU  - Konishi K
FAU - Tani, Masayuki
AU  - Tani M
FAU - Tomioka, Hiroi
AU  - Tomioka H
FAU - Kitajima, Yuka
AU  - Kitajima Y
FAU - Akashi, Norihisa
AU  - Akashi N
FAU - Inamoto, Atsuko
AU  - Inamoto A
FAU - Kurosawa, Kenzo
AU  - Kurosawa K
FAU - Yuda, Hajime
AU  - Yuda H
FAU - Hanashi, Takahiro
AU  - Hanashi T
FAU - Ouchi, Hiromi
AU  - Ouchi H
FAU - Hachisu, Mitsugu
AU  - Hachisu M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150630
PL  - Switzerland
TA  - Neurodegener Dis
JT  - Neuro-degenerative diseases
JID - 101189034
RN  - 0 (Cholinergic Antagonists)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Cholinergic Antagonists/*metabolism
MH  - Cholinesterase Inhibitors/*therapeutic use
MH  - Cognition Disorders/*drug therapy/*metabolism
MH  - Dementia
MH  - Humans
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
EDAT- 2015/07/04 06:00
MHDA- 2016/03/24 06:00
CRDT- 2015/07/04 06:00
PHST- 2015/07/04 06:00 [entrez]
PHST- 2015/07/04 06:00 [pubmed]
PHST- 2016/03/24 06:00 [medline]
AID - 000381513 [pii]
AID - 10.1159/000381513 [doi]
PST - ppublish
SO  - Neurodegener Dis. 2015;15(3):157-61. doi: 10.1159/000381513. Epub 2015 Jun 30.