PMID- 26139017
OWN - NLM
STAT- MEDLINE
DCOM- 20161014
LR  - 20181113
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 22
IP  - 1
DP  - 2016 Feb
TI  - HSV encephalitis-induced anti-NMDAR encephalitis in a 67-year-old woman: report 
      of a case and review of the literature.
PG  - 33-7
LID - 10.1007/s13365-015-0364-9 [doi]
AB  - Herpes simplex virus (HSV) encephalitis can induce an autoimmune encephalitis 
      mediated by autoantibodies against the N-methyl-D-aspartate receptor (NMDAR). 
      Post-HSV NMDAR encephalitis and de novo NMDAR encephalitis have been more 
      commonly described in children and young adults. We describe the case of a 
      67-year-old woman with post-HSV NMDAR encephalitis and review the relevant 
      literature. Clinical, serological, neurophysiological, and imaging evaluations 
      were undertaken in the evaluation of this patient. A literature review was 
      performed. Nearly 2 months after a typical course of HSV encephalitis confirmed 
      by HSV polymerase chain reaction studies from the spinal fluid and treated with 
      intravenous acyclovir, a 67-year-old woman suffered neurological deterioration. 
      There was no evidence of active HSV infection, but NMDAR antibodies were found in 
      her serum and spinal fluid. The patient improved after initiation of 
      immunosuppressive therapy. All patients who experience new or recurrent 
      neurological symptoms following recovery from HSV encephalitis should be 
      evaluated for post-infectious autoimmune encephalitis, including NMDAR 
      encephalitis.
FAU - Morris, Nicholas A
AU  - Morris NA
AD  - Department of Neurology, Columbia University Medical Center, New York, 10032, NY, 
      USA. nam2185@cumc.columbia.edu.
FAU - Kaplan, Tamara B
AU  - Kaplan TB
AD  - Department of Neurology, Brigham & Women's Hospital, Boston, MA, 02114, USA. 
      tbkaplan@partners.org.
AD  - Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA. 
      tbkaplan@partners.org.
FAU - Linnoila, Jenny
AU  - Linnoila J
AD  - Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA. 
      jlinnoila@partners.org.
FAU - Cho, Tracey
AU  - Cho T
AD  - Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA. 
      tcho@partners.org.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150703
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Antiviral Agents)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Viral Proteins)
RN  - 4F4X42SYQ6 (Rituximab)
RN  - EC 2.7.7.7 (DNA-Directed DNA Polymerase)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir/therapeutic use
MH  - Aged
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/drug 
      therapy/etiology/pathology/*virology
MH  - Antiviral Agents/*therapeutic use
MH  - Autoantibodies/cerebrospinal fluid
MH  - DNA-Directed DNA Polymerase/cerebrospinal fluid/genetics
MH  - Encephalitis, Herpes Simplex/complications/drug therapy/pathology/*virology
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Rituximab/therapeutic use
MH  - Simplexvirus/genetics/growth & development/pathogenicity
MH  - Viral Proteins/cerebrospinal fluid/genetics
OTO - NOTNLM
OT  - All neuropsychology/behavior
OT  - Autoimmune diseases
OT  - Encephalitis
OT  - Post-infectious
OT  - Viral infections
EDAT- 2015/07/04 06:00
MHDA- 2016/10/16 06:00
CRDT- 2015/07/04 06:00
PHST- 2015/04/14 00:00 [received]
PHST- 2015/06/16 00:00 [accepted]
PHST- 2015/06/05 00:00 [revised]
PHST- 2015/07/04 06:00 [entrez]
PHST- 2015/07/04 06:00 [pubmed]
PHST- 2016/10/16 06:00 [medline]
AID - 10.1007/s13365-015-0364-9 [pii]
AID - 10.1007/s13365-015-0364-9 [doi]
PST - ppublish
SO  - J Neurovirol. 2016 Feb;22(1):33-7. doi: 10.1007/s13365-015-0364-9. Epub 2015 Jul 
      3.