PMID- 26140042
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150703
LR  - 20201001
IS  - 1598-2629 (Print)
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Linking)
VI  - 15
IP  - 3
DP  - 2015 Jun
TI  - The Role of Dendritic Cells in Central Tolerance.
PG  - 111-20
LID - 10.4110/in.2015.15.3.111 [doi]
AB  - Dendritic cells (DCs) play a significant role in establishing self-tolerance 
      through their ability to present self-antigens to developing T cells in the 
      thymus. DCs are predominantly localized in the medullary region of thymus and 
      present a broad range of self-antigens, which include tissue-restricted antigens 
      expressed and transferred from medullary thymic epithelial cells, circulating 
      antigens directly captured by thymic DCs through coticomedullary junction blood 
      vessels, and peripheral tissue antigens captured and transported by peripheral 
      tissue DCs homing to the thymus. When antigen-presenting DCs make a high affinity 
      interaction with antigen-specific thymocytes, this interaction drives the 
      interacting thymocytes to death, a process often referred to as negative 
      selection, which fundamentally blocks the self-reactive thymocytes from 
      differentiating into mature T cells. Alternatively, the interacting thymocytes 
      differentiate into the regulatory T (Treg) cells, a distinct T cell subset with 
      potent immune suppressive activities. The specific mechanisms by which thymic DCs 
      differentiate Treg cells have been proposed by several laboratories. Here, we 
      review the literatures that elucidate the contribution of thymic DCs to negative 
      selection and Treg cell differentiation, and discusses its potential mechanisms 
      and future directions.
FAU - Oh, Jaehak
AU  - Oh J
AD  - Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, 
      University of California San Francisco, San Francisco, CA 94143, USA.
FAU - Shin, Jeoung-Sook
AU  - Shin JS
AD  - Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, 
      University of California San Francisco, San Francisco, CA 94143, USA.
LA  - eng
GR  - R01 GM105800/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20150625
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC4486773
OTO - NOTNLM
OT  - Central tolerance
OT  - Clonal deletion
OT  - Dendritic cell
OT  - Negative selection
OT  - Regulatory T cell
OT  - Thymus
COIS- CONFLICTS OF INTEREST: The authors have no financial conflict of interest.
EDAT- 2015/07/04 06:00
MHDA- 2015/07/04 06:01
PMCR- 2015/06/01
CRDT- 2015/07/04 06:00
PHST- 2015/03/31 00:00 [received]
PHST- 2015/05/26 00:00 [revised]
PHST- 2015/06/02 00:00 [accepted]
PHST- 2015/07/04 06:00 [entrez]
PHST- 2015/07/04 06:00 [pubmed]
PHST- 2015/07/04 06:01 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - 10.4110/in.2015.15.3.111 [doi]
PST - ppublish
SO  - Immune Netw. 2015 Jun;15(3):111-20. doi: 10.4110/in.2015.15.3.111. Epub 2015 Jun 
      25.