PMID- 26140541
OWN - NLM
STAT- MEDLINE
DCOM- 20160325
LR  - 20181113
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 7
IP  - 7
DP  - 2015 Jul 1
TI  - Postprandial Responses to Lipid and Carbohydrate Ingestion in Repeated 
      Subcutaneous Adipose Tissue Biopsies in Healthy Adults.
PG  - 5347-61
LID - 10.3390/nu7075224 [doi]
AB  - Adipose tissue is a primary site of meta-inflammation. Diet composition 
      influences adipose tissue metabolism and a single meal can drive an inflammatory 
      response in postprandial period. This study aimed to examine the effect lipid and 
      carbohydrate ingestion compared with a non-caloric placebo on adipose tissue 
      response. Thirty-three healthy adults (age 24.5 +/- 3.3 year (mean +/- standard 
      deviation (SD)); body mass index (BMI) 24.1 +/- 3.2 kg/m2, were randomised into one 
      of three parallel beverage groups; placebo (water), carbohydrate (maltodextrin) 
      or lipid (dairy-cream). Subcutaneous, abdominal adipose tissue biopsies and serum 
      samples were collected prior to (0 h), as well as 2 h and 4 h after consumption 
      of the beverage. Adipose tissue gene expression levels of monocyte 
      chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6) and tumor necrosis 
      factor-alpha (TNF-alpha) increased in all three groups, without an increase in 
      circulating TNF-alpha. Serum leptin (0.6-fold, p = 0.03) and adipose tissue leptin 
      gene expression levels (0.6-fold, p = 0.001) decreased in the hours following the 
      placebo beverage, but not the nutrient beverages. Despite increased inflammatory 
      cytokine gene expression in adipose tissue with all beverages, suggesting a 
      confounding effect of the repeated biopsy method, differences in metabolic 
      responses of adipose tissue and circulating adipokines to ingestion of lipid and 
      carbohydrate beverages were observed.
FAU - Dordevic, Aimee L
AU  - Dordevic AL
AD  - School of Exercise & Nutrition Sciences, Deakin University, Victoria 3125, 
      Australia. aimee.dordevic@monash.edu.
AD  - Department of Nutrition & Dietetics, Monash University, Victoria 3168, Australia. 
      aimee.dordevic@monash.edu.
FAU - Pendergast, Felicity J
AU  - Pendergast FJ
AD  - School of Exercise & Nutrition Sciences, Deakin University, Victoria 3125, 
      Australia. fpenderg@deakin.edu.au.
FAU - Morgan, Han
AU  - Morgan H
AD  - School of Biological Sciences, University of Auckland, Auckland 1142, New 
      Zealand. t.han@auckland.ac.nz.
FAU - Villas-Boas, Silas
AU  - Villas-Boas S
AD  - School of Biological Sciences, University of Auckland, Auckland 1142, New 
      Zealand. s.villas-boas@auckland.ac.nz.
FAU - Caldow, Marissa K
AU  - Caldow MK
AD  - School of Exercise & Nutrition Sciences, Deakin University, Victoria 3125, 
      Australia. marissa.caldow@unimelb.edu.au.
AD  - Basic and Clinical Myology Laboratory, Department of Physiology, University of 
      Melbourne, Victoria 3010, Australia. marissa.caldow@unimelb.edu.au.
FAU - Larsen, Amy E
AU  - Larsen AE
AD  - School of Exercise & Nutrition Sciences, Deakin University, Victoria 3125, 
      Australia. a.larsen@latrobe.edu.au.
AD  - Department of Physiology, Anatomy and Microbiology, College of Science, Health 
      and Engineering, LaTrobe University, Victoria 3086, Australia. 
      a.larsen@latrobe.edu.au.
FAU - Sinclair, Andrew J
AU  - Sinclair AJ
AD  - Department of Nutrition & Dietetics, Monash University, Victoria 3168, Australia. 
      andrew.sinclair@deakin.edu.au.
AD  - Metabolic Research Unit, Deakin University, Waurn Ponds, Victoria 3216, 
      Australia. andrew.sinclair@deakin.edu.au.
FAU - Cameron-Smith, David
AU  - Cameron-Smith D
AD  - School of Exercise & Nutrition Sciences, Deakin University, Victoria 3125, 
      Australia. d.cameron-smith@auckland.ac.nz.
AD  - Liggins Institute, University of Auckland, Auckland 1142, New Zealand. 
      d.cameron-smith@auckland.ac.nz.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150701
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Drinking Water)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (Lipids)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Beverages
MH  - Biopsy
MH  - Body Mass Index
MH  - Chemokine CCL2/metabolism
MH  - Dietary Carbohydrates/*administration & dosage/blood
MH  - Dietary Fats/*administration & dosage
MH  - Drinking Water/metabolism
MH  - Eating
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Leptin/blood
MH  - Lipids/blood
MH  - Male
MH  - Postprandial Period/*drug effects
MH  - Subcutaneous Fat, Abdominal/*metabolism/pathology
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Young Adult
PMC - PMC4517001
OTO - NOTNLM
OT  - adipokine
OT  - adipose tissue
OT  - biopsy
OT  - inflammation
OT  - postprandial
EDAT- 2015/07/04 06:00
MHDA- 2016/03/26 06:00
PMCR- 2015/07/01
CRDT- 2015/07/04 06:00
PHST- 2015/06/03 00:00 [received]
PHST- 2015/06/24 00:00 [revised]
PHST- 2015/06/24 00:00 [accepted]
PHST- 2015/07/04 06:00 [entrez]
PHST- 2015/07/04 06:00 [pubmed]
PHST- 2016/03/26 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - nu7075224 [pii]
AID - nutrients-07-05224 [pii]
AID - 10.3390/nu7075224 [doi]
PST - epublish
SO  - Nutrients. 2015 Jul 1;7(7):5347-61. doi: 10.3390/nu7075224.