PMID- 26141030
OWN - NLM
STAT- MEDLINE
DCOM- 20170127
LR  - 20170127
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 33
IP  - 2
DP  - 2015 Jun
TI  - Effects of Xingbi gel on leukotriene E4 and immunoglobulin E production and nasal 
      eosinophilia in a guinea pig model for allergic rhinitis.
PG  - 99-106
LID - 10.12932/AP0473.33.1.201510.12932/AP0520.33.2.2015 [doi]
AB  - BACKGROUND: Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal 
      airways.Many therapies do not have immediate effects,even which have 
      side-effects.However,the effects of Xingbi gel for the treatment of AR was 
      investigated. OBJECTIVE: We investigated the effects of Xingbi gel on serum 
      levels of leukotriene E4 (LTE4) and immunoglobulin E (IgE), as well as eosinophil 
      counts in the nasal mucosa using a guinea pig model of allergic rhinitis (AR). 
      METHODS: In addition to a healthy control group without AR, guinea pigs with AR 
      were randomly divided into untreated AR control group, low-dose Xingbi gel 
      (0.2483 g/mL) group, high-dose Xingbi gel (0.4966 g/mL) group, and budesonide 
      group. RESULTS: Compared to the healthy controls, untreated AR guinea pigs had 
      significantly higher ethology scores, serum LTE4 and IgE levels, and nasal mucosa 
      eosinophil counts (p <0.01). Treatments with low-dose Xingbi gel, high-dose 
      Xingbi gel, and budesonide significantly reduced the ethology scores, serum LTE4 
      and IgE levels, and nasal mucosa eosinophil counts as compared to untreated AR 
      model guinea pigs (p <0.01). CONCLUSION: Xingbi gel alleviates AR in part through 
      inhibiting LTE4 and IgE production and reducing eosinophilia in the nasal mucosa.
FAU - Ai, Si
AU  - Ai S
AD  - Fujian University of Traditional Chinese Medicine, Huatuo Road No. 1 Minhou 
      County, Fuzhou 350122, China.
FAU - Zheng, Jian
AU  - Zheng J
FAU - Chu, Ke-Dan
AU  - Chu KD
FAU - Zhang, Hong-Sheng
AU  - Zhang HS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Gels)
RN  - 0 (xingbi)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 51333-22-3 (Budesonide)
RN  - 75715-89-8 (Leukotriene E4)
SB  - IM
MH  - Administration, Intranasal
MH  - Animals
MH  - Anti-Allergic Agents/administration & dosage/*pharmacology
MH  - Biomarkers/blood
MH  - Budesonide/pharmacology
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/administration & dosage/*pharmacology
MH  - Eosinophilia/blood/*drug therapy/immunology
MH  - Gels
MH  - Guinea Pigs
MH  - Immunoglobulin E/*blood/immunology
MH  - Leukotriene E4/*blood/immunology
MH  - Male
MH  - Nasal Mucosa/*drug effects/immunology/metabolism
MH  - Rhinitis, Allergic/blood/*drug therapy/immunology
EDAT- 2015/07/05 06:00
MHDA- 2017/01/28 06:00
CRDT- 2015/07/05 06:00
PHST- 2014/05/16 00:00 [received]
PHST- 2014/08/15 00:00 [accepted]
PHST- 2015/07/05 06:00 [entrez]
PHST- 2015/07/05 06:00 [pubmed]
PHST- 2017/01/28 06:00 [medline]
AID - 10.12932/AP0473.33.1.201510.12932/AP0520.33.2.2015 [doi]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2015 Jun;33(2):99-106. doi: 
      10.12932/AP0473.33.1.201510.12932/AP0520.33.2.2015.