PMID- 26141032
OWN - NLM
STAT- MEDLINE
DCOM- 20170127
LR  - 20170127
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 33
IP  - 2
DP  - 2015 Jun
TI  - Association of soluble human leukocyte antigen-G with acute tubular necrosis in 
      kidney transplant recipients.
PG  - 117-22
LID - 10.12932/AP0528.33.2.2015 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA)-G is a nonclassical HLA class I 
      molecule that displays strong immune-inhibitory properties and has been 
      associated with allograft acceptance. However, there are conflicting data on the 
      correlation of soluble HLA-G (sHLA-G) and acute rejection and no data on the 
      correlation with acute tubular necrosis in kidney transplantation. OBJECTIVE: To 
      evaluate the association of sHLA-G level in early post-transplant period and 
      allograft rejection/ and acute tubular necrosis (ATN) in kidney transplant 
      recipients. METHODS: The sera procured before transplantation and serially on day 
      3 and day 7 after transplantation from 76 kidney transplant recipients were 
      analyzed for the level of sHLA-G by enzyme-linked immunosorbent assay. RESULTS: 
      The levels of sHLA-G from three serial sera did not differ between patients with 
      acute rejection and patients without rejection. However, the sHLA-G levels on day 
      3 post-transplant and day 7 post-transplant in patients with ATN were 
      significantly higher than that in patients without ATN (16.3 vs 9.85 U/ml, p = 
      0.018, for day 3 post-transplant and 12.47 vs 5.42 U/ml, p = 0.044, for day 7 
      post-transplant). In addition, the ROC analysis of sHLA-G for identifying 
      patients with ATN showed that the area under curve was 0.67 (95% confidence 
      interval 0.54-0.80). CONCLUSIONS: There was no significant difference for sHLA-G 
      levels between patients with acute rejection and without rejection. 
      Interestingly, high levels of sHLA-G in day 3 and day 7 after transplantation 
      were associated with acute tubular necrosis. Our findings raise the question 
      whether the increased levels of sHLA-G in patients with acute tubular necrosis 
      after transplantation might be a result of ischemia and reperfusion injury.
FAU - Krongvorakul, Jatupon
AU  - Krongvorakul J
AD  - Histocompatibility and Immunogenetics Laboratory, Department of Pathology, 
      Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Kantachuvesiri, Surasak
AU  - Kantachuvesiri S
FAU - Ingsathit, Atiporn
AU  - Ingsathit A
FAU - Rattanasiri, Sasivimol
AU  - Rattanasiri S
FAU - Mongkolsuk, Tasanee
AU  - Mongkolsuk T
FAU - Kitpoka, Pimpun
AU  - Kitpoka P
FAU - Thammanichanond, Duangtawan
AU  - Thammanichanond D
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Biomarkers)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Adult
MH  - Allografts
MH  - Area Under Curve
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Graft Rejection/blood/diagnosis/*immunology
MH  - HLA-G Antigens/blood/*immunology
MH  - Humans
MH  - Kidney Transplantation/*adverse effects
MH  - Kidney Tubular Necrosis, Acute/blood/diagnosis/*immunology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Solubility
MH  - Time Factors
MH  - Up-Regulation
EDAT- 2015/07/05 06:00
MHDA- 2017/01/28 06:00
CRDT- 2015/07/05 06:00
PHST- 2014/06/03 00:00 [received]
PHST- 2014/08/13 00:00 [accepted]
PHST- 2015/07/05 06:00 [entrez]
PHST- 2015/07/05 06:00 [pubmed]
PHST- 2017/01/28 06:00 [medline]
AID - 10.12932/AP0528.33.2.2015 [doi]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2015 Jun;33(2):117-22. doi: 
      10.12932/AP0528.33.2.2015.