PMID- 26141273
OWN - NLM
STAT- MEDLINE
DCOM- 20151013
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1406
DP  - 2015 Aug 7
TI  - Development and evaluation of electromembrane extraction across a hollow polymer 
      inclusion membrane.
PG  - 34-9
LID - S0021-9673(15)00867-5 [pii]
LID - 10.1016/j.chroma.2015.06.020 [doi]
AB  - In this work, a new variation of the electromembrane extraction (EME) approach 
      employing a hollow polymer inclusion membrane (HPIM) was developed. In this 
      method, a HPIM was prepared by casting a solution of the desired proportions of 
      cellulose acetate (CTA), tris(2-ethylhexyl)phosphate (TEHP) and 
      di-(2-ethylhexyl)phosphoric acid (D2EHPA) in dichloromethane on glass capillary 
      tubing. Three basic drugs namely amphetamine, methamphetamine, and 
      3,4-methylenedioxy-N-methylamphetamine (MDMA) were selected as model analytes to 
      evaluate the extraction performance of this new approach. The drugs were 
      extracted from human plasma samples, through a 20mum thickness HPIM, to an aqueous 
      acceptor solution inside the lumen of the hollow membrane. Parameters affecting 
      the extraction efficiency were investigated in detail. Under the optimized 
      conditions, enrichment factors in the range of 97-103-fold were obtained from 3mL 
      of sample solution with a 10min extraction time and an applied voltage of 300V 
      across the HPIM. The detection limits of the method for the three drugs were in 
      the range of 1.0-2.5ng/mL (at a signal/noise ratio of three), with relative 
      standard deviations of between 6.4% and 7.9%. When the method was applied to 
      spiked plasma samples, the relative recoveries ranged from 99.2% to 100.8%. 
      Enrichment factors of 103, 99 and 97 were obtained for amphetamine, 
      methamphetamine, and MDMA, respectively. A comparison was also made between the 
      newly developed approach and EME using supported liquid membranes (SLM) as well 
      as standard sample preparation methods (liquid-liquid extraction) used by the 
      Toxicology Unit, Department of Chemistry, Malaysia.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Mamat, Nor Akma
AU  - Mamat NA
AD  - Centre for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and 
      Industrial Research, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, 
      Malaysia; Department of Chemistry, Faculty of Science, Universiti Teknologi 
      Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia.
FAU - See, Hong Heng
AU  - See HH
AD  - Centre for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and 
      Industrial Research, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, 
      Malaysia; Department of Chemistry, Faculty of Science, Universiti Teknologi 
      Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia; Australian Centre for Research 
      on Separation Science, School of Physical Sciences - Chemistry, University of 
      Tasmania, Private Bag 75, Hobart 7001, Tasmania, Australia. Electronic address: 
      hhsee@ibnusina.utm.my.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150619
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Amphetamines)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Organophosphates)
RN  - 0 (Polymers)
RN  - 3J2P07GVB6 (acetylcellulose)
RN  - 44RAL3456C (Methamphetamine)
RN  - 9004-34-6 (Cellulose)
RN  - BQC0BKB72S (tris(2-ethylhexyl)phosphate)
SB  - IM
MH  - Amphetamines/*analysis/blood
MH  - Blood Chemical Analysis/*methods
MH  - Cellulose/analogs & derivatives/chemistry
MH  - Humans
MH  - Limit of Detection
MH  - Malaysia
MH  - Membranes, Artificial
MH  - Methamphetamine/analysis/blood
MH  - Organophosphates/chemistry
MH  - Polymers/chemistry
OTO - NOTNLM
OT  - Capillary electrophoresis
OT  - Drugs
OT  - Electromembrane extraction
OT  - Plasma
OT  - Polymer inclusion membrane
EDAT- 2015/07/05 06:00
MHDA- 2015/10/16 06:00
CRDT- 2015/07/05 06:00
PHST- 2015/05/02 00:00 [received]
PHST- 2015/06/09 00:00 [revised]
PHST- 2015/06/09 00:00 [accepted]
PHST- 2015/07/05 06:00 [entrez]
PHST- 2015/07/05 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - S0021-9673(15)00867-5 [pii]
AID - 10.1016/j.chroma.2015.06.020 [doi]
PST - ppublish
SO  - J Chromatogr A. 2015 Aug 7;1406:34-9. doi: 10.1016/j.chroma.2015.06.020. Epub 
      2015 Jun 19.