PMID- 26141483
OWN - NLM
STAT- MEDLINE
DCOM- 20160928
LR  - 20220317
IS  - 2212-1692 (Electronic)
IS  - 1875-9572 (Linking)
VI  - 57
IP  - 1
DP  - 2016 Feb
TI  - Serum Lactate, Brain Magnetic Resonance Imaging and Outcome of Neonatal Hypoxic 
      Ischemic Encephalopathy after Therapeutic Hypothermia.
PG  - 35-40
LID - S1875-9572(15)00084-4 [pii]
LID - 10.1016/j.pedneo.2015.04.008 [doi]
AB  - BACKGROUND: Serum lactate was used to predict the severity and outcome of 
      neonatal hypoxic ischemic encephalopathy (HIE) before the era of therapeutic 
      hypothermia (TH). There is no report on neurodevelopment (ND) outcome of neonates 
      with HIE treated with TH in Taiwan. METHODS: Between April 2011 and December 
      2012, newborn infants admitted to Chang Gung Memorial Hospital (CGMH), with 
      gestational age > 35 weeks and birth weight >/= 1800 g, who had acute perinatal 
      events, evidence of significant fetal compromise, and ongoing clinical 
      encephalopathy were prospectively enrolled for TH. Whole body cooling method was 
      used to maintain the affected neonate's esophageal temperature at 33.5 +/- 0.5  degrees C 
      for 72 hours. Demographic data were recorded and hemogram, biochemical 
      parameters, serum lactate, and creatine kinase (CK) were measured as well. Brain 
      magnetic resonance imaging (MRI) was performed between 7 and 14 days of life. ND 
      outcome of infants was evaluated by Bayley Scales of Infant Development, third 
      edition (BSID-III) at 24 months of corrected age. Poor ND (PND) outcome was 
      defined as infants surviving with either disability or ND delay. RESULTS: 
      Seventeen patients were enrolled. Fifty-nine percent of babies (10/17) were born 
      through cesarean section and 77% of babies (13/17) were transferred from outside 
      hospitals. Six babies were moderate HIE and 11 babies were severe HIE. Among the 
      14 surviving patients, eight infants had PND outcome. There was no difference in 
      demographic data between infants with and without PND. Serum level of lactate 
      (mg/dL) after 72 hours of TH was higher (35.6 vs. 13.8, p = 0.042) in infants 
      with PND. Neonates with abnormal brain MRI findings were also associated with PND 
      (p = 0.01). CONCLUSION: This is the first report on ND outcome of neonates with 
      HIE treated with TH in Taiwan. Higher serum level of lactate following TH and 
      abnormal results of brain MRI are associated with poor ND outcome.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Chiang, Ming-Chou
AU  - Chiang MC
AD  - Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan; Division of Respiratory Therapy, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung 
      University College of Medicine, Taoyuan, Taiwan. Electronic address: 
      newborntw@gmail.com.
FAU - Lien, Reyin
AU  - Lien R
AD  - Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan; Division of Respiratory Therapy, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan.
FAU - Chu, Shih-Ming
AU  - Chu SM
AD  - Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan; Division of Respiratory Therapy, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan.
FAU - Yang, Peng-Hong
AU  - Yang PH
AD  - Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan; Division of Respiratory Therapy, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan.
FAU - Lin, Jainn-Jim
AU  - Lin JJ
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University College of 
      Medicine, Taoyuan, Taiwan; Division of Pediatric Neurology, Department of 
      Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Hsu, Jen-Fu
AU  - Hsu JF
AD  - Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan.
FAU - Fu, Ren-Huei
AU  - Fu RH
AD  - Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, 
      Taoyuan, Taiwan.
FAU - Lin, Kuang-Lin
AU  - Lin KL
AD  - Division of Pediatric Neurology, Department of Pediatrics, Chang Gung Memorial 
      Hospital, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20150527
PL  - Singapore
TA  - Pediatr Neonatol
JT  - Pediatrics and neonatology
JID - 101484755
RN  - 0 (Lactates)
SB  - IM
CIN - Pediatr Neonatol. 2017 Dec;58(6):563. PMID: 28919357
MH  - Brain/growth & development/*pathology
MH  - Child Development
MH  - Female
MH  - Humans
MH  - *Hypothermia, Induced
MH  - Hypoxia-Ischemia, Brain/blood/pathology/physiopathology/*therapy
MH  - Infant
MH  - Infant, Newborn
MH  - Lactates/*blood
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Prospective Studies
OTO - NOTNLM
OT  - biomarkers
OT  - hypoxic ischemic encephalopathy
OT  - lactate
OT  - outcome
OT  - therapeutic hypothermia
EDAT- 2015/07/05 06:00
MHDA- 2016/09/30 06:00
CRDT- 2015/07/05 06:00
PHST- 2014/10/28 00:00 [received]
PHST- 2015/01/13 00:00 [revised]
PHST- 2015/04/01 00:00 [accepted]
PHST- 2015/07/05 06:00 [entrez]
PHST- 2015/07/05 06:00 [pubmed]
PHST- 2016/09/30 06:00 [medline]
AID - S1875-9572(15)00084-4 [pii]
AID - 10.1016/j.pedneo.2015.04.008 [doi]
PST - ppublish
SO  - Pediatr Neonatol. 2016 Feb;57(1):35-40. doi: 10.1016/j.pedneo.2015.04.008. Epub 
      2015 May 27.