PMID- 26142696
OWN - NLM
STAT- MEDLINE
DCOM- 20160622
LR  - 20220330
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 29
IP  - 7
DP  - 2015 Oct
TI  - In vitro evaluation of the cytotoxicity and modulation of mechanisms associated 
      with inflammation induced by perfluorooctanesulfonate and perfluorooctanoic acid 
      in human colon myofibroblasts CCD-18Co.
PG  - 1683-91
LID - S0887-2333(15)00162-9 [pii]
LID - 10.1016/j.tiv.2015.07.001 [doi]
AB  - Perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the most 
      notable members of an emerging class of persistent organic pollutants (POPs), 
      poly- and perfluoroalkyl acids (PFASs). In this study, the CCD-18Co 
      myofibroblasts were selected as a cell model to investigate the cytotoxic effects 
      of PFOS and PFOA. The aim was to perform an in vitro evaluation of the ability of 
      these compounds to induce cytotoxicity and modulate mechanisms associated with 
      inflammation as measured by (i) colon fibroblasts viability, (ii) colon 
      fibroblasts proliferation, and (iii) IL-6 production. The data provided in this 
      study suggest that PFOS and PFOA can have cytotoxic potential and modulate 
      processes associated with intestinal inflammation such as myofibroblasts 
      proliferation and IL-6 production at concentrations similar to those detected in 
      vivo. Our results also highlight the influence of culture serum concentration in 
      cytotoxic in vitro studies, which should be considered in future toxicity studies 
      involving PFOS and PFOA. The results contribute to a better knowledge of the 
      effects of PFOS and PFOA in human cells, a phenomenon still not fully examined.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Gimenez-Bastida, Juan Antonio
AU  - Gimenez-Bastida JA
AD  - Department of Chemistry and Biodynamics of Food, Institute of Animal Reproduction 
      and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, 
      Poland. Electronic address: juan.gimenez-bastida@pan.olsztyn.pl.
FAU - Surma, Magdalena
AU  - Surma M
AD  - Malopolska Centre of Food Monitoring, Faculty of Food Technology, University of 
      Agriculture in Krakow, Balicka St. 122, 30-149 Krakow, Poland. Electronic 
      address: m.surma@ur.krakow.pl.
FAU - Zielinski, Henryk
AU  - Zielinski H
AD  - Department of Chemistry and Biodynamics of Food, Institute of Animal Reproduction 
      and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, 
      Poland. Electronic address: h.zielinski@pan.oldztyn.pl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150702
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with 
      BIBRA
JID - 8712158
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Alkanesulfonic Acids/*toxicity
MH  - Caprylates/*toxicity
MH  - Cell Line
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Colon/cytology
MH  - Environmental Pollutants/*toxicity
MH  - Fluorocarbons/*toxicity
MH  - Humans
MH  - Inflammation/metabolism
MH  - Interleukin-6/metabolism
MH  - Myofibroblasts/cytology/*drug effects/metabolism
OTO - NOTNLM
OT  - Inflammation
OT  - Myofibroblasts CCD18-Co
OT  - Perfluorooctanesulfonate
OT  - Perfluorooctanoic acid
OT  - Polyfluoroalkyl and perfluoroalkyl acids
EDAT- 2015/07/06 06:00
MHDA- 2016/06/23 06:00
CRDT- 2015/07/06 06:00
PHST- 2015/04/02 00:00 [received]
PHST- 2015/06/29 00:00 [revised]
PHST- 2015/07/01 00:00 [accepted]
PHST- 2015/07/06 06:00 [entrez]
PHST- 2015/07/06 06:00 [pubmed]
PHST- 2016/06/23 06:00 [medline]
AID - S0887-2333(15)00162-9 [pii]
AID - 10.1016/j.tiv.2015.07.001 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2015 Oct;29(7):1683-91. doi: 10.1016/j.tiv.2015.07.001. Epub 
      2015 Jul 2.