PMID- 26143581
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20150831
IS  - 1873-2399 (Electronic)
IS  - 0301-472X (Linking)
VI  - 43
IP  - 9
DP  - 2015 Sep
TI  - Two new routes to make blood: Hematopoietic specification from pluripotent cell 
      lines versus reprogramming of somatic cells.
PG  - 756-9
LID - S0301-472X(15)00189-7 [pii]
LID - 10.1016/j.exphem.2015.05.007 [doi]
AB  - Transplantation of hematopoietic stem cells (HSCs) to treat hematologic disorders 
      is routinely used in the clinic. However, HSC therapy is hindered by the 
      requirements of finding human leukocyte antigen (HLA)-matched donors and 
      attaining sufficient numbers of long-term HSCs in the graft. Therefore, ex vivo 
      expansion of transplantable HSCs remains one of the "holy grails" of hematology. 
      Without the ability to maintain and expand human HSCs in vitro, two complementary 
      approaches involving cellular reprogramming to generate transplantable HSCs have 
      emerged. Reprogrammed HSCs represent a potentially inexhaustible supply of 
      autologous tissue. On March 18th, 2015, Dr. George Q. Daley and Dr. Derrick J. 
      Rossi, two pioneers in the field, presented and discussed their most recent 
      research on these topics in a webinar organized by the International Society for 
      Experimental Hematology (ISEH). Here, we summarize these seminars and discuss the 
      possibilities and challenges in the field of hematopoietic specification.
CI  - Copyright (c) 2015 ISEH - International Society for Experimental Hematology. 
      Published by Elsevier Inc. All rights reserved.
FAU - Singbrant, Sofie
AU  - Singbrant S
AD  - Department of Molecular Medicine, Lund Stem Cell Center, Lund University, Lund, 
      Sweden. Electronic address: sofie.singbrant@med.lu.se.
FAU - van Galen, Peter
AU  - van Galen P
AD  - Department of Pathology, Massachusetts General Hospital and Harvard Medical 
      School, Boston, MA, USA.
FAU - Lucas, Daniel
AU  - Lucas D
AD  - Department of Cell and Developmental Biology, University of Michigan Medical 
      School, Ann Arbor, MI, USA.
FAU - Challen, Grant
AU  - Challen G
AD  - Division of Developmental, Regenerative and Stem Cell Biology & Division of 
      Oncology, Washington University School of Medicine, St. Louis, MO, USA.
FAU - Rossi, Derrick J
AU  - Rossi DJ
AD  - Department of Stem Cell and Regenerative Biology, Harvard University, Harvard 
      Medical School, Program in Cellular and Molecular Medicine, Division of 
      Hematology and Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, 
      Cambridge, MA, USA.
FAU - Daley, George Q
AU  - Daley GQ
AD  - Stem Cell Transplantation Program, Division of Hematology and Oncology, Boston 
      Children's Hospital, Harvard Medical School, Harvard Stem Cell Institute, 
      Cambridge, MA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150702
PL  - Netherlands
TA  - Exp Hematol
JT  - Experimental hematology
JID - 0402313
SB  - IM
MH  - Animals
MH  - Cellular Reprogramming
MH  - *Hematologic Diseases/genetics/metabolism/pathology/therapy
MH  - *Hematopoietic Stem Cells/metabolism/pathology
MH  - Humans
MH  - *Pluripotent Stem Cells/metabolism/pathology
EDAT- 2015/07/06 06:00
MHDA- 2015/11/17 06:00
CRDT- 2015/07/06 06:00
PHST- 2015/05/06 00:00 [received]
PHST- 2015/05/07 00:00 [accepted]
PHST- 2015/07/06 06:00 [entrez]
PHST- 2015/07/06 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - S0301-472X(15)00189-7 [pii]
AID - 10.1016/j.exphem.2015.05.007 [doi]
PST - ppublish
SO  - Exp Hematol. 2015 Sep;43(9):756-9. doi: 10.1016/j.exphem.2015.05.007. Epub 2015 
      Jul 2.