PMID- 26146622
OWN - NLM
STAT- MEDLINE
DCOM- 20160318
LR  - 20220409
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: 
      Applications and Therapies.
PG  - 549412
LID - 10.1155/2015/549412 [doi]
LID - 549412
AB  - The cardiovascular system ensures the delivery of oxygen and nutrients to all 
      cells, tissues, and organs. Under extended exposure to reduced oxygen levels, 
      cells are able to survive through the transcriptional activation of a series of 
      genes that participate in angiogenesis, glucose metabolism, and cell 
      proliferation. The oxygen-sensitive transcriptional activator HIF-1 
      (hypoxia-inducible factor-1) is a key transcriptional mediator of the response to 
      hypoxic conditions. The HIF-1 pathway was found to be a master regulator of 
      angiogenesis. Whether the process is physiological or pathological, HIF-1 seems 
      to participate in vasculature formation by synergistic correlations with other 
      proangiogenic factors such as VEGF (vascular endothelial growth factor), PlGF 
      (placental growth factor), or angiopoietins. Considering the important 
      contributions of HIF-1 in angiogenesis and vasculogenesis, it should be 
      considered a promising target for treating ischaemic diseases or cancer. In this 
      review, we discuss the roles of HIF-1 in both physiological/pathophysiological 
      angiogenesis and potential strategies for clinical therapy.
FAU - Zimna, Agnieszka
AU  - Zimna A
AD  - Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 
      Poznan, Poland.
FAU - Kurpisz, Maciej
AU  - Kurpisz M
AD  - Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 
      Poznan, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150604
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (PGF protein, human)
RN  - 0 (Pregnancy Proteins)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 144589-93-5 (Placenta Growth Factor)
SB  - IM
MH  - Cell Hypoxia
MH  - Humans
MH  - Hypoxia/genetics
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
MH  - Neovascularization, Pathologic/*genetics
MH  - Neovascularization, Physiologic/*genetics
MH  - Placenta Growth Factor
MH  - Pregnancy Proteins/genetics
MH  - Transcriptional Activation
MH  - Vascular Endothelial Growth Factor A/genetics
PMC - PMC4471260
EDAT- 2015/07/07 06:00
MHDA- 2016/03/19 06:00
PMCR- 2015/06/04
CRDT- 2015/07/07 06:00
PHST- 2014/12/19 00:00 [received]
PHST- 2015/04/10 00:00 [revised]
PHST- 2015/04/17 00:00 [accepted]
PHST- 2015/07/07 06:00 [entrez]
PHST- 2015/07/07 06:00 [pubmed]
PHST- 2016/03/19 06:00 [medline]
PHST- 2015/06/04 00:00 [pmc-release]
AID - 10.1155/2015/549412 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:549412. doi: 10.1155/2015/549412. Epub 2015 Jun 4.