PMID- 26148074
OWN - NLM
STAT- MEDLINE
DCOM- 20151106
LR  - 20181023
IS  - 1016-5169 (Print)
IS  - 1016-5169 (Linking)
VI  - 43
IP  - 5
DP  - 2015 Jul
TI  - Lymphocytopenia is associated with poor NYHA functional class in chronic heart 
      failure patients with reduced ejection fraction.
PG  - 427-33
LID - 10.5543/tkda.2015.89439 [doi]
AB  - OBJECTIVE: In heart failure (HF) patients, functional capacity has been 
      demonstrated to be a marker of poor prognosis, independent of left ventricular 
      ejection fraction (EF). Lymphocyte count is currently recognized in certain risk 
      stratification scores for chronic HF, and severe HF is associated with 
      lymphocytopenia. However, no data exists on the association between lymphocyte 
      count and functional capacity in patients with stable HF. This study aimed to 
      assess the relationship between lymphocyte count and New York Heart Association 
      (NYHA) functional capacity in systolic HF outpatients. METHODS: The Turkish 
      Research Team-HF (TREAT-HF) is a network which undertakes multi-center 
      observational studies in HF. Data on 392 HF reduced ejection fraction (HFREF) 
      patients from 8 HF centers are presented here. The patients were divided into two 
      groups and compared: Group 1 comprised stable HFREF patients with mild symptoms 
      (NYHA Class I-II), while Group 2 consisted of patients with NYHA Class III-IV 
      symptoms. RESULTS: Patient mean age was 60+/-14 years. Lymphocyte count was lower 
      in patients with NYHA functional classes III and IV than in patients with NYHA 
      functional classes I and II, (0.9 [0.6-1.5]x1000 versus 1.5 [0.7-2.2]x1000, 
      p<0.001). In multivariate logistic regression analysis, lymphocyte count (OR: 
      0.602, 95% CI: 0.375-0.967, p=0.036), advanced age, male gender, presence of 
      hypertension, EF, left atrium size, systolic pulmonary artery pressure, 
      neutrophil and basophil counts, creatinine level, and diuretic usage were 
      associated with poor NYHA functional class in systolic HF outpatients. 
      CONCLUSION: The present study demonstrated that in stable HFREF outpatients, 
      lymphocytopenia was strongly associated with poor NYHA function, independent of 
      coronary heart disease risk factors.
FAU - Yucel, Hasan
AU  - Yucel H
AD  - Department of Cardiology, Cumhuriyet University Faculty of Medicine, Sivas, 
      Turkey.
FAU - Refiker Ege, Meltem
AU  - Refiker Ege M
AD  - Department of Cardiology, Private Sincan Koru Hospital, Ankara, Turkey.
FAU - Zorlu, Ali
AU  - Zorlu A
AD  - Department of Cardiology, Cumhuriyet University Faculty of Medicine, Sivas, 
      Turkey.
FAU - Kaya, Hakki
AU  - Kaya H
AD  - Department of Cardiology, Cumhuriyet University Faculty of Medicine, Sivas, 
      Turkey.
FAU - Beton, Osman
AU  - Beton O
AD  - Department of Cardiology, Cumhuriyet University Faculty of Medicine, Sivas, 
      Turkey.
FAU - Gungor, Hasan
AU  - Gungor H
AD  - Department of Cardiology, Adnan Menderes University Faculty of Medicine, Aydin, 
      Turkey.
FAU - Acar, Gurkan
AU  - Acar G
AD  - Department of Cardiology, Sutcu Imam University Faculty of Medicine, 
      Kahramanmaras, Turkey.
FAU - Temizhan, Ahmet
AU  - Temizhan A
AD  - Department of Cardiology, Yuksek Ihtisas Hospital, Ankara, Turkey.
FAU - Cavusoglu, Yuksel
AU  - Cavusoglu Y
AD  - Department of Cardiology, Osmangazi University Faculty of Medicine, Eskisehir, 
      Turkey.
FAU - Zoghi, Mehdi
AU  - Zoghi M
AD  - Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
FAU - Eren, Mehmet
AU  - Eren M
AD  - Department of Cardiology, Siyami Ersek Training and Research Hospital, Istanbul, 
      Turkey.
FAU - Ural, Dilek
AU  - Ural D
AD  - Department of Cardiology, Kocaeli University Faculty of Medicine, Kocaeli, 
      Turkey.
FAU - Yilmaz, Mehmet Birhan
AU  - Yilmaz MB
AD  - Department of Cardiology, Cumhuriyet University Faculty of Medicine, Sivas, 
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Turkey
TA  - Turk Kardiyol Dern Ars
JT  - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
JID - 9426239
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Female
MH  - Heart Failure/blood/*complications/*epidemiology/*physiopathology
MH  - Humans
MH  - Lymphopenia/*complications/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Stroke Volume
MH  - Turkey
EDAT- 2015/07/07 06:00
MHDA- 2015/11/07 06:00
CRDT- 2015/07/07 06:00
PHST- 2015/07/07 06:00 [entrez]
PHST- 2015/07/07 06:00 [pubmed]
PHST- 2015/11/07 06:00 [medline]
AID - 10.5543/tkda.2015.89439 [doi]
PST - ppublish
SO  - Turk Kardiyol Dern Ars. 2015 Jul;43(5):427-33. doi: 10.5543/tkda.2015.89439.