PMID- 26148140
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20181113
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 39
IP  - 8
DP  - 2015 Aug
TI  - Comparison of Traditional and Novel Self-Report Measures to an Alcohol Biomarker 
      for Quantifying Alcohol Consumption Among HIV-Infected Adults in Sub-Saharan 
      Africa.
PG  - 1518-27
LID - 10.1111/acer.12781 [doi]
AB  - BACKGROUND: In Sub-Saharan Africa (SSA), HIV-infected patients may underreport 
      alcohol consumption. We compared self-reports of drinking to phosphatidylethanol 
      (PEth), an alcohol biomarker. In particular, we assessed beverage-type-adjusted 
      fractional graduated frequency (FGF) and quantity frequency (QF) measures of 
      grams of alcohol, novel nonvolume measures, and the Alcohol Use Disorders 
      Identification Test-Consumption (AUDIT-C). METHODS: We analyzed cohort entry data 
      from the Biomarker Research of Ethanol Among Those with HIV cohort study (2011 to 
      2013). Participants were HIV-infected past-year drinkers, newly enrolled into 
      care. Self-report measures included FGF and QF grams of alcohol, the AUDIT-C, 
      number of drinking days, and novel adaptations of FGF and QF methods to 
      expenditures on alcohol, time spent drinking, and symptoms of intoxication. PEth 
      levels were measured from dried blood spots. We calculated Spearman's rank 
      correlation coefficients of self-reports with PEth and bias-corrected bootstrap 
      95% confidence intervals (CIs) for pairwise differences between coefficients. 
      RESULTS: A total of 209 subjects (57% men) were included. Median age was 30; 
      interquartile range (IQR) 25 to 38. FGF grams of alcohol over the past 90 days 
      (median 592, IQR 43 to 2,137) were higher than QF grams (375, IQR 33 to 1,776), p 
      < 0.001. However, both measures were moderately correlated with PEth: rho = 0.58, 
      95% CI 0.47 to 0.66 for FGF grams and 0.54, 95% CI 0.43 to 0.63 for QF grams (95% 
      CI for difference -0.017 to 0.099, not statistically significant). AUDIT-C, time 
      drinking, and a scale of symptoms of intoxication were similarly correlated with 
      PEth (rho = 0.35 to 0.57). CONCLUSIONS: HIV-infected drinkers in SSA likely 
      underreport both any alcohol consumption and amounts consumed, suggesting the 
      need to use more objective measures like biomarkers when measuring drinking in 
      this population. Although the FGF method may more accurately estimate drinking 
      than QF methods, the AUDIT-C and other nonvolume measures may provide simpler 
      alternatives.
CI  - Copyright (c) 2015 by the Research Society on Alcoholism.
FAU - Asiimwe, Stephen B
AU  - Asiimwe SB
AD  - Department of Medicine, Mbarara Regional Referral Hospital, Mbarara, Uganda.
AD  - Department of Epidemiology and Biostatistics, University of California, San 
      Francisco, California.
FAU - Fatch, Robin
AU  - Fatch R
AD  - Department of Medicine, University of California, San Francisco, California.
FAU - Emenyonu, Nneka I
AU  - Emenyonu NI
AD  - Department of Medicine, University of California, San Francisco, California.
FAU - Muyindike, Winnie R
AU  - Muyindike WR
AD  - Department of Medicine, Mbarara Regional Referral Hospital, Mbarara, Uganda.
AD  - Department of Medicine, Mbarara University of Science and Technology, Mbarara, 
      Uganda.
FAU - Kekibiina, Allen
AU  - Kekibiina A
AD  - Department of Medicine, Mbarara University of Science and Technology, Mbarara, 
      Uganda.
FAU - Santos, Glenn-Milo
AU  - Santos GM
AD  - San Francisco Department of Public Health, San Francisco, California.
AD  - Department of Community Health Systems, University of California, San Francisco, 
      California.
FAU - Greenfield, Thomas K
AU  - Greenfield TK
AUID- ORCID: 0000-0002-3108-4812
AD  - Alcohol Research Group, Public Health Institute, Emeryville, California.
FAU - Hahn, Judith A
AU  - Hahn JA
AD  - Department of Epidemiology and Biostatistics, University of California, San 
      Francisco, California.
AD  - Department of Medicine, University of California, San Francisco, California.
LA  - eng
GR  - R01 AA018631/AA/NIAAA NIH HHS/United States
GR  - P30 AA005595/AA/NIAAA NIH HHS/United States
GR  - P30 DK026743/DK/NIDDK NIH HHS/United States
GR  - P50 AA005595/AA/NIAAA NIH HHS/United States
GR  - U01 AA020776/AA/NIAAA NIH HHS/United States
GR  - P30 AI027763/AI/NIAID NIH HHS/United States
GR  - K24 AA022586/AA/NIAAA NIH HHS/United States
GR  - R01 AA013309/AA/NIAAA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150704
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Biomarkers)
RN  - 0 (Glycerophospholipids)
RN  - 0 (phosphatidylethanol)
SB  - IM
MH  - Adult
MH  - Africa South of the Sahara/epidemiology
MH  - Alcohol Drinking/*blood/*epidemiology
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glycerophospholipids/*blood
MH  - HIV Infections/*blood/diagnosis/*epidemiology
MH  - Humans
MH  - Male
MH  - Self Report/*standards
PMC - PMC4515166
MID - NIHMS692229
OTO - NOTNLM
OT  - Fractional Graduated Frequency
OT  - Phosphatidylethanol
OT  - Quantity Frequency
OT  - Self-Report Measures of Alcohol Consumption
OT  - Sub-Saharan Africa
EDAT- 2015/07/07 06:00
MHDA- 2016/05/03 06:00
PMCR- 2016/08/01
CRDT- 2015/07/07 06:00
PHST- 2014/11/17 00:00 [received]
PHST- 2015/05/11 00:00 [accepted]
PHST- 2015/07/07 06:00 [entrez]
PHST- 2015/07/07 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - 10.1111/acer.12781 [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2015 Aug;39(8):1518-27. doi: 10.1111/acer.12781. Epub 2015 
      Jul 4.