PMID- 26149103
OWN - NLM
STAT- MEDLINE
DCOM- 20160405
LR  - 20181202
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 179
IP  - 3-4
DP  - 2015 Sep 30
TI  - Comparison of two genetically distant type 2 porcine reproductive and respiratory 
      syndrome virus (PRRSV) modified live vaccines against Vietnamese highly 
      pathogenic PRRSV.
PG  - 233-41
LID - S0378-1135(15)00249-7 [pii]
LID - 10.1016/j.vetmic.2015.06.013 [doi]
AB  - Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) 
      known as pig high fever disease was first reported in China and has spread 
      rapidly in neighboring southeastern Asian countries. The objective of this study 
      was to evaluate the efficacy of a new type 2 PRRSV modified live vaccine (vaccine 
      A) against a challenge with a HP-PRRSV and to compare the efficacy of two 
      genetically distant type 2 PRRSV modified vaccines (vaccine A for lineage 8 and 
      vaccine B for lineage 5) against HP-PRRSV (lineage 8) challenge. Pigs were 
      divided into 4 groups (n=12/group); vaccinated challenged (2 groups), 
      unvaccinated challenged, and unvaccinated unchallenged groups. Regardless of 
      vaccines, vaccinated challenged pigs showed significantly lower (P<0.05) mean 
      rectal temperatures and respiratory scores, levels of HP-PRRSV viremia, and lung 
      lesions and HP-PRRSV antigens within lung lesions compared to unvaccinated 
      challenged pigs. Vaccinated challenged pigs had significantly higher (P<0.05) 
      numbers of interferon-gamma secreting cells (IFN-gamma-SC) compared to unvaccinated 
      challenged pigs. Significant differences were also found when comparing two type 
      2 PRRSV vaccines after HP-PRRSV challenge. The use of type 2 PRRSV vaccine A was 
      able to significantly reduce fever when compared to type 2 PRRSV vaccine B in 
      vaccinated challenged pigs. Vaccination of pigs with vaccine A reduced viral 
      loads in their blood and induced higher numbers of HP-PRRSV-specific IFN-gamma-SC 
      than vaccination of pigs with vaccine B. This study demonstrates partial 
      protection of two genetically distant type 2 PRRSV vaccines against HP-PRRSV 
      challenge in growing pigs.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Do, Duy Tien
AU  - Do DT
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea; 
      Faculty of Animal Husbandry and Veterinary Medicine, Nonglam University, Thu Duc 
      District, Ho Chi Minh City, Vietnam.
FAU - Park, Changhoon
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Choi, Kyuhyung
AU  - Choi K
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Nguyen, Toan Tat
AU  - Nguyen TT
AD  - Faculty of Animal Husbandry and Veterinary Medicine, Nonglam University, Thu Duc 
      District, Ho Chi Minh City, Vietnam.
FAU - Nguyen, Khang Duong
AU  - Nguyen KD
AD  - Faculty of Animal Husbandry and Veterinary Medicine, Nonglam University, Thu Duc 
      District, Ho Chi Minh City, Vietnam.
FAU - Vo, Dai Tan
AU  - Vo DT
AD  - Faculty of Animal Husbandry and Veterinary Medicine, Nonglam University, Thu Duc 
      District, Ho Chi Minh City, Vietnam.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150626
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cluster Analysis
MH  - Interferon-gamma/immunology
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome 
      virus/*genetics/*immunology/pathogenicity
MH  - Real-Time Polymerase Chain Reaction/veterinary
MH  - Sequence Alignment
MH  - Sus scrofa/*immunology
MH  - Swine
MH  - Vaccination/*veterinary
MH  - Vaccines, Attenuated/immunology
MH  - Vietnam
MH  - Viral Vaccines/*immunology
MH  - Viremia/immunology
OTO - NOTNLM
OT  - Comparison
OT  - Highly pathogenic porcine reproductive and respiratory syndrome virus
OT  - Protection
OT  - Vaccine
EDAT- 2015/07/08 06:00
MHDA- 2016/04/06 06:00
CRDT- 2015/07/08 06:00
PHST- 2015/04/27 00:00 [received]
PHST- 2015/06/18 00:00 [revised]
PHST- 2015/06/19 00:00 [accepted]
PHST- 2015/07/08 06:00 [entrez]
PHST- 2015/07/08 06:00 [pubmed]
PHST- 2016/04/06 06:00 [medline]
AID - S0378-1135(15)00249-7 [pii]
AID - 10.1016/j.vetmic.2015.06.013 [doi]
PST - ppublish
SO  - Vet Microbiol. 2015 Sep 30;179(3-4):233-41. doi: 10.1016/j.vetmic.2015.06.013. 
      Epub 2015 Jun 26.