PMID- 26149581
OWN - NLM
STAT- MEDLINE
DCOM- 20160428
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 86
IP  - 2
DP  - 2015 Aug
TI  - HLA genetic diversity in Hungarians and Hungarian Gypsies: complementary 
      differentiation patterns and demographic signals revealed by HLA-A, -B and -DRB1 
      in Central Europe.
PG  - 115-21
LID - 10.1111/tan.12600 [doi]
AB  - Systematic analyses of human leukocyte antigen (HLA) profiles in different 
      populations may increase the efficiency of bone marrow donor selection and help 
      reconstructing human peopling history. We typed HLA-A, -B, and -DRB1 allele 
      groups in two bone marrow donor cohorts of 2402 Hungarians and 186 Hungarian 
      Gypsies and compared them with several Central-European, Spanish Gypsy, and 
      Indian populations. Our results indicate that different European Gypsy 
      populations share a common origin but diverged genetically as a consequence of 
      founder effect and rapid genetic drift, whereas other European populations are 
      related genetically in relation to geography. This study also suggests that while 
      HLA-A accurately depicts the effects of genetic drift, HLA-B, and -DRB1 conserve 
      more signatures of ancient population relationships, as a result of balancing 
      selection.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Inotai, D
AU  - Inotai D
AD  - Laboratory of Transplantation Immunogenetics, Hungarian National Blood 
      Transfusion Service, Budapest, Hungary.
FAU - Szilvasi, A
AU  - Szilvasi A
AD  - Laboratory of Transplantation Immunogenetics, Hungarian National Blood 
      Transfusion Service, Budapest, Hungary.
FAU - Benko, S
AU  - Benko S
AD  - Laboratory of Transplantation Immunogenetics, Hungarian National Blood 
      Transfusion Service, Budapest, Hungary.
FAU - Boros-Major, A
AU  - Boros-Major A
AD  - Laboratory of Transplantation Immunogenetics, Hungarian National Blood 
      Transfusion Service, Budapest, Hungary.
FAU - Illes, Z
AU  - Illes Z
AD  - Laboratory of Transplantation Immunogenetics, Hungarian National Blood 
      Transfusion Service, Budapest, Hungary.
FAU - Bors, A
AU  - Bors A
AD  - Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, 
      Hungary.
FAU - Kiss, K P
AU  - Kiss KP
AD  - Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, 
      Hungary.
FAU - Rajczy, K
AU  - Rajczy K
AD  - Bone Marrow Donor Registry, Hungarian Blood Transfusion Service, Budapest, 
      Hungary.
FAU - Gelle-Hosso, A
AU  - Gelle-Hosso A
AD  - Bone Marrow Donor Registry, Hungarian Blood Transfusion Service, Budapest, 
      Hungary.
FAU - Buhler, S
AU  - Buhler S
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution - Anthropology Unit, University of Geneva, Geneva, Switzerland.
FAU - Nunes, J M
AU  - Nunes JM
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution - Anthropology Unit, University of Geneva, Geneva, Switzerland.
FAU - Sanchez-Mazas, A
AU  - Sanchez-Mazas A
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution - Anthropology Unit, University of Geneva, Geneva, Switzerland.
FAU - Tordai, A
AU  - Tordai A
AD  - Laboratory of Transplantation Immunogenetics, Hungarian National Blood 
      Transfusion Service, Budapest, Hungary.
AD  - Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, 
      Hungary.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150707
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Bone Marrow Transplantation
MH  - Female
MH  - Founder Effect
MH  - Genetic Drift
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Hungary
MH  - Male
MH  - Middle Aged
MH  - Phylogeography
MH  - *Polymorphism, Genetic
MH  - *Roma
MH  - Tissue Donors
MH  - *White People
OTO - NOTNLM
OT  - Gypsies
OT  - Hungary
OT  - balancing selection
OT  - bone marrow donors
OT  - genetic diversity
OT  - genetic drift
OT  - human leukocyte antigen
OT  - human leukocyte antigen evolution
OT  - population genetics
EDAT- 2015/07/08 06:00
MHDA- 2016/04/29 06:00
CRDT- 2015/07/08 06:00
PHST- 2015/02/11 00:00 [received]
PHST- 2015/05/13 00:00 [revised]
PHST- 2015/06/02 00:00 [accepted]
PHST- 2015/07/08 06:00 [entrez]
PHST- 2015/07/08 06:00 [pubmed]
PHST- 2016/04/29 06:00 [medline]
AID - 10.1111/tan.12600 [doi]
PST - ppublish
SO  - Tissue Antigens. 2015 Aug;86(2):115-21. doi: 10.1111/tan.12600. Epub 2015 Jul 7.