PMID- 26152818
OWN - NLM
STAT- MEDLINE
DCOM- 20160307
LR  - 20181202
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 49
DP  - 2015 Aug
TI  - Lacosamide in status epilepticus: Update on the TRENdS study.
PG  - 337-9
LID - S1525-5050(15)00349-2 [pii]
LID - 10.1016/j.yebeh.2015.06.018 [doi]
AB  - Many patients with critical illness have been noted to have nonconvulsive 
      seizures (NCSs) and nonconvulsive status epilepticus (NCSE). How aggressively 
      these seizures should be treated is unclear. Many investigators feel that the 
      morbidity of NCSs and NCSE is different from that of generalized convulsive 
      status epilepticus (GCSE), so treatment should be less urgent. Consequently, many 
      nonsedating AEDs have been used to treat NCSs and NCSE in patients with critical 
      illness. Randomized, controlled trials demonstrating the efficacy of AEDs in NCSs 
      and NCSE are lacking. The Treatment of Recurrent Electrographic Nonconvulsive 
      Seizures (TRENdS) study compared lacosamide to fosphenytoin in the treatment of 
      NCSs. An update of the study is presented. This article is part of a Special 
      Issue entitled "Status Epilepticus".
CI  - Published by Elsevier Inc.
FAU - Husain, Aatif M
AU  - Husain AM
AD  - Department of Neurology, Duke University Medical Center and Neurodiagnostic 
      Center, Veterans Affairs Medical Center, Durham, NC, USA. Electronic address: 
      aatif.husain@duke.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150704
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
RN  - 0 (Acetamides)
RN  - 0 (Anticonvulsants)
RN  - 563KS2PQY5 (Lacosamide)
RN  - 6158TKW0C5 (Phenytoin)
RN  - B4SF212641 (fosphenytoin)
SB  - IM
MH  - Acetamides/*therapeutic use
MH  - Anticonvulsants/*therapeutic use
MH  - Critical Illness/therapy
MH  - Humans
MH  - Lacosamide
MH  - Phenytoin/analogs & derivatives/therapeutic use
MH  - Recurrence
MH  - Seizures
MH  - Status Epilepticus/*drug therapy
OTO - NOTNLM
OT  - Continuous EEG monitoring
OT  - Electrographic seizures
OT  - Fosphenytoin
OT  - Lacosamide
OT  - Nonconvulsive seizures
EDAT- 2015/07/15 06:00
MHDA- 2016/03/08 06:00
CRDT- 2015/07/09 06:00
PHST- 2015/04/18 00:00 [received]
PHST- 2015/06/07 00:00 [revised]
PHST- 2015/06/08 00:00 [accepted]
PHST- 2015/07/09 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/03/08 06:00 [medline]
AID - S1525-5050(15)00349-2 [pii]
AID - 10.1016/j.yebeh.2015.06.018 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2015 Aug;49:337-9. doi: 10.1016/j.yebeh.2015.06.018. Epub 2015 
      Jul 4.