PMID- 26152882
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20211203
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 57
IP  - 2
DP  - 2015 Oct
TI  - The Impact of Chronic Early Administration of Psychostimulants on Brain 
      Expression of BDNF and Other Neuroplasticity-Relevant Proteins.
PG  - 231-42
LID - 10.1007/s12031-015-0611-9 [doi]
AB  - Frequently, healthy individuals, children, and students are using stimulants to 
      treat attention deficit hyperactivity disorder (ADHD)-like symptoms or to enhance 
      cognitive capacity, attention and concentration. Methylphenidate, the most common 
      treatment for ADHD, similarly to cocaine, blocks the dopamine reuptake, leading 
      to increase in dopamine level in the synaptic cleft. Brain-derived neurotrophic 
      factor (BDNF) and other neuroplasticity-relevant proteins have a major role in 
      cellular plasticity during development and maturation of the brain. Young Sprague 
      Dawley rats (postnatal days (PND) 14) were treated chronically with either 
      cocaine or methylphenidate. The rats were examined behaviorally and biochemically 
      at several time points (PND 35, 56, 70, and 90). We found age-dependent, but 
      stimulant-independent, alterations in the mRNA expression levels of 
      microtubule-associated protein tau, doublecortin, and synaptophysin. The PND 90 
      rats, treated with methylphenidate at an early age, exhibited increased BDNF 
      protein levels in the prefrontal cortex compared to the saline-treated group. 
      Despite the treatment effects at the biochemical level, cocaine and 
      methylphenidate treatments at an early age had only minor effects on the 
      behavioral parameters measured at older ages. The biochemical alterations may 
      reflect neuroprotective or neuroplastic effects of chronic methylphenidate 
      treatment at an early age.
FAU - Simchon Tenenbaum, Yaarit
AU  - Simchon Tenenbaum Y
AD  - Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv 
      University, Ramat Aviv, 69978, Tel-Aviv, Israel.
FAU - Weizman, Abraham
AU  - Weizman A
AD  - Research Unit, Geha Mental Health Center and Felsenstein Medical Research Center, 
      Petah-Tikva, Israel.
FAU - Rehavi, Moshe
AU  - Rehavi M
AD  - Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv 
      University, Ramat Aviv, 69978, Tel-Aviv, Israel. mrehavi@post.tau.ac.il.
AD  - The Dr. Miriam and Sheldon G. Adelson Chair and Center for the Biology of 
      Addictive Diseases, Tel-Aviv, Israel. mrehavi@post.tau.ac.il.
LA  - eng
PT  - Journal Article
DEP - 20150708
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Synaptophysin)
RN  - 0 (tau Proteins)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/growth & development/metabolism/physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Central Nervous System Stimulants/administration & dosage/*pharmacology
MH  - Cocaine/administration & dosage/*pharmacology
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - Male
MH  - Methylphenidate/administration & dosage/*pharmacology
MH  - Microtubule-Associated Proteins/genetics/metabolism
MH  - Neuronal Plasticity/drug effects
MH  - Neuropeptides/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synaptophysin/genetics/metabolism
MH  - tau Proteins/genetics/metabolism
OTO - NOTNLM
OT  - Attention deficit hyperactivity disorder (ADHD)
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Cocaine
OT  - Doublecortin (DCX)
OT  - Methylphenidate (MPH)
EDAT- 2015/07/15 06:00
MHDA- 2016/06/18 06:00
CRDT- 2015/07/09 06:00
PHST- 2015/06/25 00:00 [received]
PHST- 2015/06/26 00:00 [accepted]
PHST- 2015/07/09 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
AID - 10.1007/s12031-015-0611-9 [pii]
AID - 10.1007/s12031-015-0611-9 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2015 Oct;57(2):231-42. doi: 10.1007/s12031-015-0611-9. Epub 2015 
      Jul 8.