PMID- 26153151
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20150822
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 125
IP  - 9
DP  - 2015 Sep
TI  - MicroRNA-34c-5p is related to recurrence in laryngeal squamous cell carcinoma.
PG  - E306-12
LID - 10.1002/lary.25475 [doi]
AB  - OBJECTIVES/HYPOTHESIS: Altered microRNA expression has been found in many cancer 
      types, including laryngeal squamous cell carcinoma (LSCC). We investigated the 
      association of LSCC-related miR-34c-5p with disease-free survival and overall 
      survival. STUDY DESIGN: Retrospective cohort study. METHODS: Expression levels of 
      miR-34c-5p were detected in 90 LSCC formalin-fixed paraffin-embedded tissues by 
      reverse-transcription quantitative polymerase chain reaction. Overall survival 
      and disease-free survival were evaluated using the Kaplan-Meier method, and 
      multivariate analysis was performed using Cox proportional hazard analysis. 
      RESULTS: A downregulation of miR-34c-5p expression significantly correlated with 
      worse disease-free and overall survival. In the multivariate analysis, low 
      miR-34c-5p expression was associated with an increased risk of recurrence. 
      CONCLUSIONS: A downregulation of miR-34c-5p in LSCC is independently associated 
      with unfavorable disease-free survival, suggesting that miR-34c-5p might be a 
      promising marker for evaluating the risk of recurrences. LEVEL OF EVIDENCE: NA.
CI  - (c) 2015 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Re, Massimo
AU  - Re M
AD  - Department of Otorhinolaryngology, Umberto I University General Hospital, 
      Polytechnic University of the Marches, Ancona, Italy.
FAU - Ceka, Artan
AU  - Ceka A
AD  - Department of Molecular and Clinical Sciences, Polytechnic University of the 
      Marches, Ancona, Italy.
FAU - Rubini, Corrado
AU  - Rubini C
AD  - Pathologic Anatomy and Histopathology Division, Department of Biomedical Sciences 
      and Public Health, Polytechnic University of the Marches, Ancona, Italy.
FAU - Ferrante, Luigi
AU  - Ferrante L
AD  - Department of Biomedical Sciences and Public Health, Section of Medical 
      Statistics, Faculty of Medicine, Polytechnic University of the Marches, Ancona, 
      Italy.
FAU - Zizzi, Antonio
AU  - Zizzi A
AD  - Pathologic Anatomy and Histopathology Division, Department of Biomedical Sciences 
      and Public Health, Polytechnic University of the Marches, Ancona, Italy.
FAU - Gioacchini, Federico M
AU  - Gioacchini FM
AD  - Department of Otorhinolaryngology, Umberto I University General Hospital, 
      Polytechnic University of the Marches, Ancona, Italy.
FAU - Tulli, Michele
AU  - Tulli M
AD  - Department of Otorhinolaryngology, Umberto I University General Hospital, 
      Polytechnic University of the Marches, Ancona, Italy.
FAU - Spazzafumo, Liana
AU  - Spazzafumo L
AD  - Center of Biostatistics, National Institute of Repose and Cure for 
      Elderly-Scientific Institute for Hospitalization and Treatment (INRCA-IRCCS) 
      Italian National Institute, Ancona, Italy.
FAU - Sellari-Franceschini, Stefano
AU  - Sellari-Franceschini S
AD  - Department of Otorhinolaryngology, University of Pisa, Pisa, Italy.
FAU - Procopio, Antonio D
AU  - Procopio AD
AD  - Department of Molecular and Clinical Sciences, Polytechnic University of the 
      Marches, Ancona, Italy.
AD  - Center of Clinical Pathology and Innovative Therapy, INRCA-IRCCS Italian National 
      Institute, Ancona, Italy.
FAU - Olivieri, Fabiola
AU  - Olivieri F
AD  - Department of Molecular and Clinical Sciences, Polytechnic University of the 
      Marches, Ancona, Italy.
AD  - Center of Clinical Pathology and Innovative Therapy, INRCA-IRCCS Italian National 
      Institute, Ancona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150707
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (MIRN34 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Neoplasm)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics/mortality/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Italy/epidemiology
MH  - Laryngeal Neoplasms/*genetics/mortality/pathology
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*genetics/mortality/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - RNA, Neoplasm/*genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - biomarkers
OT  - miR-34c-5p
OT  - microRNA
OT  - prognosis
OT  - recurrence
EDAT- 2015/07/15 06:00
MHDA- 2015/11/13 06:00
CRDT- 2015/07/09 06:00
PHST- 2015/02/17 00:00 [received]
PHST- 2015/06/02 00:00 [revised]
PHST- 2015/06/09 00:00 [accepted]
PHST- 2015/07/09 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
AID - 10.1002/lary.25475 [doi]
PST - ppublish
SO  - Laryngoscope. 2015 Sep;125(9):E306-12. doi: 10.1002/lary.25475. Epub 2015 Jul 7.