PMID- 26153468
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20190108
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Print)
IS  - 1931-7557 (Linking)
VI  - 9
IP  - 3
DP  - 2015 Sep
TI  - Hyper-connectivity of the thalamus during early stages following mild traumatic 
      brain injury.
PG  - 550-63
LID - 10.1007/s11682-015-9424-2 [doi]
AB  - The thalamo-cortical resting state functional connectivity of seven sub-thalamic 
      regions were examined in a prospectively recruited population of 77 acute mild 
      TBI (mTBI) patients within the first 10 days (mean 6 +/- 3 days) of injury and 35 
      neurologically intact control subjects using the Oxford thalamic connectivity 
      atlas. Neuropsychological assessments were conducted using the Automated 
      Neuropsychological Assessment Metrics (ANAM). A subset of participants received a 
      magentic resonance spectroscopy (MRS) exam to determine metabolite concentrations 
      in the thalamus and the posterior cingulate cortex. Results show that patients 
      performed worse than the control group on various subtests of ANAM and the 
      weighted throughput score, suggesting reduced cognitive performance at this early 
      stage of injury. Both voxel and region of interest based analysis of the resting 
      state fMRI data demonstrated that acute mTBI patients have increased functional 
      connectivity between the various sub-thalamic regions and cortical regions 
      associated with sensory processing and the default mode network (DMN). In 
      addition, a significant reduction in NAA/Cr was observed in the thalamus in the 
      mTBI patients. Furthermore, an increase in Cho/Cr ratio specific to mTBI patients 
      with self-reported sensory symptoms was observed compared to those without 
      self-reported sensory symptoms. These results provide novel insights into the 
      neural mechanisms of the brain state related to internal rumination and arousal, 
      which have implications for new interventions for mTBI patients with persistent 
      symptoms. Furthermore, an understanding of heightened sensitivity to sensory 
      related inputs during early stages of injury may facilitate enhanced prediction 
      of safe return to work.
FAU - Sours, Chandler
AU  - Sours C
AD  - Magnetic Resonance Research Center, University of Maryland School of Medicine, 
      Baltimore, MD, 21201, USA.
AD  - Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland 
      School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA.
FAU - George, Elijah O
AU  - George EO
AD  - Magnetic Resonance Research Center, University of Maryland School of Medicine, 
      Baltimore, MD, 21201, USA.
AD  - Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland 
      School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA.
AD  - Department of Bioengineering, University of Maryland, College Park, MD, 20740, 
      USA.
FAU - Zhuo, Jiachen
AU  - Zhuo J
AD  - Magnetic Resonance Research Center, University of Maryland School of Medicine, 
      Baltimore, MD, 21201, USA.
AD  - Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland 
      School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA.
FAU - Roys, Steven
AU  - Roys S
AD  - Magnetic Resonance Research Center, University of Maryland School of Medicine, 
      Baltimore, MD, 21201, USA.
AD  - Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland 
      School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA.
FAU - Gullapalli, Rao P
AU  - Gullapalli RP
AD  - Magnetic Resonance Research Center, University of Maryland School of Medicine, 
      Baltimore, MD, 21201, USA. rgullapalli@umm.edu.
AD  - Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland 
      School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA. 
      rgullapalli@umm.edu.
AD  - Department of Bioengineering, University of Maryland, College Park, MD, 20740, 
      USA. rgullapalli@umm.edu.
LA  - eng
GR  - F31 NS081984/NS/NINDS NIH HHS/United States
GR  - R03 NS088014/NS/NINDS NIH HHS/United States
GR  - S10 RR019214/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Atlases as Topic
MH  - Brain Injuries/*physiopathology/psychology
MH  - Brain Mapping
MH  - Cognition
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/physiopathology
MH  - Neuropsychological Tests
MH  - Prospective Studies
MH  - Proton Magnetic Resonance Spectroscopy
MH  - Rest
MH  - Thalamus/*physiopathology
MH  - Time Factors
PMC - PMC4577461
MID - NIHMS706202
OTO - NOTNLM
OT  - 1H magnetic resonance spectroscopy
OT  - Mild traumatic brain injury
OT  - Resting state functional connectivity
OT  - Thalamus
EDAT- 2015/07/15 06:00
MHDA- 2016/06/18 06:00
PMCR- 2016/09/01
CRDT- 2015/07/09 06:00
PHST- 2015/07/09 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - 10.1007/s11682-015-9424-2 [pii]
AID - 10.1007/s11682-015-9424-2 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2015 Sep;9(3):550-63. doi: 10.1007/s11682-015-9424-2.