PMID- 26154447
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20181113
IS  - 2153-7933 (Electronic)
IS  - 2153-7658 (Print)
IS  - 2153-7658 (Linking)
VI  - 5
IP  - 4
DP  - 2015 Dec
TI  - Setting Up an Efficient Therapeutic Hypothermia Team in Conscious ST Elevation 
      Myocardial Infarction Patients: A UK Heart Attack Center Experience.
PG  - 217-22
LID - 10.1089/ther.2015.0012 [doi]
AB  - Patients presenting with ST elevation myocardial infarction (STEMI) are routinely 
      treated with percutaneous coronary intervention to restore blood flow in the 
      occluded artery to reduce infarct size (IS). However, there is evidence to 
      suggest that the restoration of blood flow can cause further damage to the 
      myocardium through reperfusion injury (RI). Recent research in this area has 
      focused on minimizing damage to the myocardium caused by RI. Therapeutic 
      hypothermia (TH) has been shown to be beneficial in animal models of coronary 
      artery occlusion in reducing IS caused by RI if instituted early in an ischemic 
      myocardium. Data in humans are less convincing to date, although exploratory 
      analyses suggest that there is significant clinical benefit in reducing IS if TH 
      can be administered at the earliest recognition of ischemia in anterior 
      myocardial infarction. The Essex Cardiothoracic Centre is the first UK center to 
      have participated in administering TH in conscious patients presenting with STEMI 
      as part of the COOL-AMI case series study. In this article, we outline our 
      experience of efficiently integrating conscious TH into our primary percutaneous 
      intervention program to achieve 18 minutes of cooling duration before 
      reperfusion, with no significant increase in door-to-balloon times, in the 
      setting of the clinical trial.
FAU - Islam, Shahed
AU  - Islam S
AD  - 1 Post-Graduate Medical Institute, Anglia Ruskin University , Chelmsford, United 
      Kingdom .
AD  - 2 Department of Cardiology, The Essex Cardiothoracic Centre (CTC) , Basildon, 
      United Kingdom .
FAU - Hampton-Till, James
AU  - Hampton-Till J
AD  - 1 Post-Graduate Medical Institute, Anglia Ruskin University , Chelmsford, United 
      Kingdom .
FAU - MohdNazri, Shah
AU  - MohdNazri S
AD  - 1 Post-Graduate Medical Institute, Anglia Ruskin University , Chelmsford, United 
      Kingdom .
AD  - 2 Department of Cardiology, The Essex Cardiothoracic Centre (CTC) , Basildon, 
      United Kingdom .
FAU - Watson, Noel
AU  - Watson N
AD  - 1 Post-Graduate Medical Institute, Anglia Ruskin University , Chelmsford, United 
      Kingdom .
AD  - 2 Department of Cardiology, The Essex Cardiothoracic Centre (CTC) , Basildon, 
      United Kingdom .
FAU - Gudde, Ellie
AU  - Gudde E
AD  - 2 Department of Cardiology, The Essex Cardiothoracic Centre (CTC) , Basildon, 
      United Kingdom .
FAU - Gudde, Tom
AU  - Gudde T
AD  - 2 Department of Cardiology, The Essex Cardiothoracic Centre (CTC) , Basildon, 
      United Kingdom .
FAU - Kelly, Paul A
AU  - Kelly PA
AD  - 1 Post-Graduate Medical Institute, Anglia Ruskin University , Chelmsford, United 
      Kingdom .
FAU - Tang, Kare H
AU  - Tang KH
AD  - 1 Post-Graduate Medical Institute, Anglia Ruskin University , Chelmsford, United 
      Kingdom .
FAU - Davies, John R
AU  - Davies JR
AD  - 1 Post-Graduate Medical Institute, Anglia Ruskin University , Chelmsford, United 
      Kingdom .
AD  - 2 Department of Cardiology, The Essex Cardiothoracic Centre (CTC) , Basildon, 
      United Kingdom .
FAU - Keeble, Thomas R
AU  - Keeble TR
AD  - 1 Post-Graduate Medical Institute, Anglia Ruskin University , Chelmsford, United 
      Kingdom .
AD  - 2 Department of Cardiology, The Essex Cardiothoracic Centre (CTC) , Basildon, 
      United Kingdom .
LA  - eng
PT  - Journal Article
DEP - 20150708
PL  - United States
TA  - Ther Hypothermia Temp Manag
JT  - Therapeutic hypothermia and temperature management
JID - 101543518
SB  - IM
MH  - *Body Temperature Regulation
MH  - *Consciousness
MH  - Critical Pathways
MH  - Delivery of Health Care/*organization & administration
MH  - *Efficiency, Organizational
MH  - England
MH  - Feasibility Studies
MH  - Humans
MH  - *Hypothermia, Induced
MH  - Myocardial Infarction/diagnosis/physiopathology/*therapy
MH  - Myocardial Reperfusion Injury/diagnosis/etiology/physiopathology/*prevention & 
      control
MH  - Patient Care Team/*organization & administration
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Risk Factors
MH  - Time Factors
MH  - Time-to-Treatment
MH  - Treatment Outcome
PMC - PMC4677568
EDAT- 2015/07/15 06:00
MHDA- 2016/09/16 06:00
PMCR- 2015/12/01
CRDT- 2015/07/09 06:00
PHST- 2015/07/09 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 10.1089/ther.2015.0012 [pii]
AID - 10.1089/ther.2015.0012 [doi]
PST - ppublish
SO  - Ther Hypothermia Temp Manag. 2015 Dec;5(4):217-22. doi: 10.1089/ther.2015.0012. 
      Epub 2015 Jul 8.