PMID- 26154883
OWN - NLM
STAT- MEDLINE
DCOM- 20160121
LR  - 20150709
IS  - 0161-6412 (Print)
IS  - 0161-6412 (Linking)
VI  - 30
IP  - 10
DP  - 2008 Dec
TI  - Nanosize titanium dioxide cause neuronal apoptosis: a potential linkage between 
      nanoparticle exposure and neural disorder.
PG  - 1115-20
LID - 10.1179/0161641215Z.000000000587 [doi]
AB  - OBJECTIVES: Nanosize titanium dioxide is used in water and air decontamination 
      and in numerous home appliances and products designed for direct human use. 
      However, the impact of nanoparticle on biological system is not known to us. 
      Therefore, it is our urgent and primary task to ascertain the information about 
      safety and potential hazards of products derived from nanomaterial to the health 
      of mankind. METHODS: We made use of MTT, bromodeoxyuridine (BrdU), and Terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assays to 
      testify the biological impact of nanosize TiO2 on olfactory bulb neurons cultured 
      in vitro. RESULTS: In this article, we elucidate the cytotoxicity of titanium 
      dioxide to olfactory bulb neurons on cellular and molecular level. We come to a 
      conclusion that nanosize titanium dioxide causes neuronal apoptosis, and it also 
      down-regulate the expression of olfactory marker protein (OMP) and tyrosine 
      hydroxylase (TH). DISCUSSION: These results show that a relationship between 
      nanoparticle exposure and pathogeny of neurodegenerative diseases may exist.
FAU - Yu, Yiqun
AU  - Yu Y
AD  - Research and Development Department, Jianrong Chemistry and Nanomaterial Limited 
      Corporation, Industrial Development Zone of Eastern Juancheng County, Shandong 
      Province, China. yyq0821@163.com
FAU - Ren, Wenwen
AU  - Ren W
FAU - Ren, Baozhong
AU  - Ren B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
EIN - Neurol Res. 2008 Dec;30(10):1121
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - DNA Fragmentation/drug effects
MH  - Metal Nanoparticles/*toxicity
MH  - Neurons/*drug effects/metabolism
MH  - Olfactory Bulb/cytology
MH  - Rats
MH  - Titanium/*toxicity
OTO - NOTNLM
OT  - Apoptosis,
OT  - Neurodegenerative disease,
OT  - Olfactory bulb neuron
OT  - Titanium dioxide,
EDAT- 2008/12/01 00:00
MHDA- 2016/01/23 06:00
CRDT- 2015/07/09 06:00
PHST- 2015/07/09 06:00 [entrez]
PHST- 2008/12/01 00:00 [pubmed]
PHST- 2016/01/23 06:00 [medline]
AID - 10.1179/0161641215Z.000000000587 [doi]
PST - ppublish
SO  - Neurol Res. 2008 Dec;30(10):1115-20. doi: 10.1179/0161641215Z.000000000587.