PMID- 26155390
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210112
IS  - 2162-4011 (Print)
IS  - 2162-402X (Electronic)
IS  - 2162-4011 (Linking)
VI  - 4
IP  - 5
DP  - 2015 May
TI  - Highly clonal regulatory T-cell population in follicular lymphoma - inverse 
      correlation with the diversity of CD8(+) T cells.
PG  - e1002728
LID - e1002728
AB  - The immune microenvironment in follicular lymphoma (FL) plays an important role 
      in controlling disease characteristics. To characterize the T-cell receptor (TCR) 
      repertoire in follicular lymphoma (FL) tissues, we applied a next-generation 
      sequencing platform and deeply sequenced TCR cDNAs of T-cell subset populations 
      present in pretreatment FL biopsy specimens. T regulatory cell (T(reg)) TCRs in 
      FL tissues revealed a highly oligoclonal expansion compared to those in control 
      lymph nodes. Furthermore, an inverse correlation was observed between the 
      diversity of T(reg) and CD8(+) TCRs in FL specimens. Interestingly, a tumor from 
      an FL patient, who had not received anticancer treatment for more than 10 years, 
      was found to have missense mutations in the peptide-binding domain of both human 
      leukocyte antigen (HLA) class I and II molecules, which might have presented 
      tumor-specific antigens and enhanced host immune responses. Although further 
      verification is required, our data suggest that the T-cell repertoire is skewed 
      and restricted in FL and support the evolving understanding of the 
      microenvironment in this disease.
FAU - Liu, Xiao
AU  - Liu X
AD  - Section of Hematology/Oncology; Department of Medicine; The University of Chicago 
      ; Chicago, IL USA.
FAU - Venkataraman, Girish
AU  - Venkataraman G
AD  - Department of Pathology; The University of Chicago ; Chicago, IL USA.
FAU - Lin, Jiaying
AU  - Lin J
AD  - Section of Hematology/Oncology; Department of Medicine; The University of Chicago 
      ; Chicago, IL USA.
FAU - Kiyotani, Kazuma
AU  - Kiyotani K
AD  - Section of Hematology/Oncology; Department of Medicine; The University of Chicago 
      ; Chicago, IL USA.
FAU - Smith, Sonali
AU  - Smith S
AD  - Section of Hematology/Oncology; Department of Medicine; The University of Chicago 
      ; Chicago, IL USA.
FAU - Montoya, Magdeline
AU  - Montoya M
AD  - Section of Hematology/Oncology; Department of Medicine; The University of Chicago 
      ; Chicago, IL USA.
FAU - Nakamura, Yusuke
AU  - Nakamura Y
AD  - Section of Hematology/Oncology; Department of Medicine; The University of Chicago 
      ; Chicago, IL USA ; Department of Surgery; The University of Chicago ; Chicago, 
      IL USA.
FAU - Kline, Justin
AU  - Kline J
AD  - Section of Hematology/Oncology; Department of Medicine; The University of Chicago 
      ; Chicago, IL USA.
LA  - eng
GR  - UL1 TR000430/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20150203
PL  - United States
TA  - Oncoimmunology
JT  - Oncoimmunology
JID - 101570526
PMC - PMC4485720
OTO - NOTNLM
OT  - T-cell receptor (TCR)
OT  - follicular lymphoma (FL)
OT  - next-generation sequencing (NGS)
OT  - tumor microenvironment
EDAT- 2015/07/15 06:00
MHDA- 2015/07/15 06:01
PMCR- 2016/02/03
CRDT- 2015/07/09 06:00
PHST- 2014/11/18 00:00 [received]
PHST- 2014/12/20 00:00 [revised]
PHST- 2014/12/23 00:00 [accepted]
PHST- 2015/07/09 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/07/15 06:01 [medline]
PHST- 2016/02/03 00:00 [pmc-release]
AID - 1002728 [pii]
AID - 10.1080/2162402X.2014.1002728 [doi]
PST - epublish
SO  - Oncoimmunology. 2015 Feb 3;4(5):e1002728. doi: 10.1080/2162402X.2014.1002728. 
      eCollection 2015 May.