PMID- 26155931 OWN - NLM STAT- MEDLINE DCOM- 20161011 LR - 20181113 IS - 1347-7439 (Electronic) IS - 0916-7250 (Print) IS - 0916-7250 (Linking) VI - 77 IP - 12 DP - 2016 Jan TI - Localized pulmonary histiocytic sarcomas in Pembroke Welsh Corgi. PG - 1659-61 LID - 10.1292/jvms.15-0284 [doi] AB - Nineteen cases of histiocytic sarcomas in Pembroke Welsh Corgi were examined histopathologically. Focal or multiple masses were detected in the lung or in regional lymph nodes, or in both lung and nodes. All neoplastic lesions had common histological features characterized by the proliferation of pleomorphic histiocytic cells combined with various inflammatory cells. Most of the pleomorphic neoplastic cells were immunopositive for human leukocyte antigen (HLA)-DR and Iba-1. The median survival time for all dogs was 133 days. In the present study, several prognostic factors, such as gender, age, single or multiple lesions, lymph node involvement at the time of diagnosis, surgical resection status and additional chemotherapy, were examined, although none of these factors approached statistical significance. Histiocytic sarcoma must be considered in the differential diagnosis of dogs with pulmonary masses, especially in the canine breed. FAU - Kagawa, Yumiko AU - Kagawa Y AD - North Lab, 8-35 Hondori 2-chome Kita, Shiroishi-ku, Sapporo, Hokkaido 003-0027, Japan. FAU - Nakano, Yuko AU - Nakano Y FAU - Kobayashi, Tetsuya AU - Kobayashi T FAU - Asano, Kazushi AU - Asano K FAU - Takagi, Satoshi AU - Takagi S LA - eng PT - Journal Article DEP - 20150704 PL - Japan TA - J Vet Med Sci JT - The Journal of veterinary medical science JID - 9105360 SB - IM MH - Animals MH - Dog Diseases/*pathology MH - Dogs MH - Female MH - Histiocytic Sarcoma/pathology/*veterinary MH - Lung Neoplasms/pathology/*veterinary MH - Male PMC - PMC4710725 EDAT- 2015/07/15 06:00 MHDA- 2016/10/12 06:00 PMCR- 2015/12/01 CRDT- 2015/07/10 06:00 PHST- 2015/07/10 06:00 [entrez] PHST- 2015/07/15 06:00 [pubmed] PHST- 2016/10/12 06:00 [medline] PHST- 2015/12/01 00:00 [pmc-release] AID - 15-0284 [pii] AID - 10.1292/jvms.15-0284 [doi] PST - ppublish SO - J Vet Med Sci. 2016 Jan;77(12):1659-61. doi: 10.1292/jvms.15-0284. Epub 2015 Jul 4.