PMID- 26155996
OWN - NLM
STAT- MEDLINE
DCOM- 20180123
LR  - 20181113
IS  - 1476-5527 (Electronic)
IS  - 0950-9240 (Linking)
VI  - 30
IP  - 8
DP  - 2016 Aug
TI  - Hyperhomocysteinemia independently associated with the risk of hypertension: a 
      cross-sectional study from rural China.
PG  - 508-12
LID - 10.1038/jhh.2015.75 [doi]
AB  - This study was designed to investigate the current prevalence of 
      hyperhomocysteinemia (Hhcy) and its association with hypertension in rural adults 
      of Northeast China. A cross-sectional study was performed in subjects aged⩾35 
      years in a general Chinese population. Demographic data, laboratory examination 
      of traditional cardiovascular risk factors and self-reported information on 
      lifestyle factors, such as physical activities, current smoking and drinking 
      status, dietary habits and familial factors were collected by trained personnel. 
      A total of 7130 participants (3317 men and 3813 women) were included in this 
      study and the mean Hhcy level of the whole population was 17.39+/-12.34 mmol l(-1), 
      which was 20.99+/-14.83 mmol l(-1) in males and 14.19+/-8.51 mmol l(-1) in females, 
      respectively. Prevalence of Hhcy in total population was 41.3%. Stratified by 
      gender, the prevalence of Hhcy was higher in males than in females (59.0 vs 
      25.8%, P<0.05). After adjustment for conventional risk factors including age, 
      salt intake, smoking, body mass index, diabetes, dyslipidemia, activity time and 
      family history, multiple logistic regression analysis showed that Hhcy was 
      independently associated with the risk of hypertension in males (odds ratio 
      (OR)=1.501, 95% confidence interval (CI): 1.012-2.227; P<0.001), but not in 
      females in this population (OR=1.182; 95% CI, 0.993-1.407; P=0.060). In 
      conclusion, a high prevalence of Hhcy in the general adult population of rural 
      northeast China was detected and Hhcy may be a risk factor for hypertension, 
      particularly in males.
FAU - Li, Z
AU  - Li Z
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Guo, X
AU  - Guo X
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Chen, S
AU  - Chen S
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Zheng, L
AU  - Zheng L
AD  - Department of Clinical Epidemiology, Library, Shengjing Hospital of China Medical 
      University, Shenyang, People's Republic of China.
FAU - Yang, H
AU  - Yang H
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Sun, G
AU  - Sun G
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Yu, S
AU  - Yu S
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Li, W
AU  - Li W
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Zhou, L
AU  - Zhou L
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Wang, J
AU  - Wang J
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Hu, W
AU  - Hu W
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
FAU - Sun, Y
AU  - Sun Y
AD  - Department of Cardiology, First Hospital of China Medical University, Shenyang, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150709
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Pressure
MH  - Chi-Square Distribution
MH  - China
MH  - Cross-Sectional Studies
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/diagnosis/*epidemiology
MH  - Hypertension/diagnosis/*epidemiology/physiopathology
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Rural Health
MH  - Sex Distribution
MH  - Up-Regulation
EDAT- 2015/07/15 06:00
MHDA- 2018/01/24 06:00
CRDT- 2015/07/10 06:00
PHST- 2015/01/28 00:00 [received]
PHST- 2015/05/26 00:00 [revised]
PHST- 2015/05/29 00:00 [accepted]
PHST- 2015/07/10 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2018/01/24 06:00 [medline]
AID - jhh201575 [pii]
AID - 10.1038/jhh.2015.75 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2016 Aug;30(8):508-12. doi: 10.1038/jhh.2015.75. Epub 2015 Jul 
      9.