PMID- 26156013
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20181113
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 77
IP  - 12
DP  - 2016 Jan
TI  - Pathogenicity of emerging Japanese type 1 porcine reproductive and respiratory 
      syndrome virus in experimentally infected pigs.
PG  - 1663-6
LID - 10.1292/jvms.15-0189 [doi]
AB  - To clarify the pathogenicity of Japanese type 1 porcine reproductive and 
      respiratory syndrome virus (PRRSV) isolate in experimentally infected pigs, we 
      evaluated clinical signs and monitored viremia for 21 days post-inoculation 
      (dpi). Lungs were mottled, tanned and reddish in appearance; had lesions 
      predominantly in the cranial, middle and accessory lobes; and failed to collapse 
      at 10 dpi. Although microscopic lesions of lungs were reproduced using the 
      Japanese emerging type 1 PRRSV isolate under experimental conditions, no 
      significant differences were noted between the challenge and control groups 
      regarding mean rectal temperature and daily weight gain. These results provide 
      useful insights into the limited pathogenicity of single infection with the 
      Japanese type 1 PRRSV isolate in piglets, which differ from findings in reported 
      field cases.
FAU - Iseki, Hiroshi
AU  - Iseki H
AD  - Viral Disease and Epidemiological Research Division, National Institute of Animal 
      Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, 
      Tsukuba, Ibaraki 305-0856, Japan.
FAU - Takagi, Michihiro
AU  - Takagi M
FAU - Kawashima, Kenji
AU  - Kawashima K
FAU - Shibahara, Tomoyuki
AU  - Shibahara T
FAU - Kuroda, Yoshiko
AU  - Kuroda Y
FAU - Tsunemitsu, Hiroshi
AU  - Tsunemitsu H
FAU - Yamakawa, Makoto
AU  - Yamakawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150705
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Antibodies, Viral)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Communicable Diseases, Emerging
MH  - Japan/epidemiology
MH  - Kidney/virology
MH  - Liver/virology
MH  - Lung/virology
MH  - Palatine Tonsil/virology
MH  - Porcine Reproductive and Respiratory Syndrome
MH  - Porcine respiratory and reproductive syndrome virus/classification/*pathogenicity
MH  - RNA, Viral/immunology
MH  - Spleen/virology
MH  - Swine/*virology
MH  - Viral Load
MH  - Viremia
MH  - Virulence
PMC - PMC4710726
EDAT- 2015/07/15 06:00
MHDA- 2016/10/12 06:00
PMCR- 2015/12/01
CRDT- 2015/07/10 06:00
PHST- 2015/07/10 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 15-0189 [pii]
AID - 10.1292/jvms.15-0189 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2016 Jan;77(12):1663-6. doi: 10.1292/jvms.15-0189. Epub 2015 Jul 
      5.