PMID- 26156043
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20181202
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 26
IP  - 2
DP  - 2016
TI  - MMP-3 can distinguish isolated PMR from PMR with GCA: A retrospective study 
      regarding PMR and GCA in Japan.
PG  - 259-64
LID - 10.3109/14397595.2015.1071304 [doi]
AB  - OBJECTIVE: We sought to identify clinical features at diagnosis that can 
      distinguish isolated polymyalgia rheumatica (PMR) without giant cell arteritis 
      (GCA) from PMR with GCA, and clinical features at diagnosis of isolated PMR that 
      can predict subsequent relapse and corticosteroid discontinuation. METHODS: A 
      retrospective study of 115 patients with isolated PMR and 29 patients with GCA 
      was performed. A comparison between isolated PMR patients, GCA patients (with or 
      without PMR), and PMR with GCA patients was performed. Predictors of relapse and 
      corticosteroid discontinuation were identified using a logistic regression in the 
      patients with isolated PMR. RESULTS: Matrix metalloproteinase-3 (MMP-3) level was 
      significantly different among the patient groups. MMP-3: 230.5 +/- 201.5 ng/mL in 
      isolated PMR, 80.5 +/- 47.5 ng/mL in GCA (p < 0.01), and 96.8 +/- 54.8 ng/mL in PMR 
      with GCA (p = 0.03). In the patients with isolated PMR, female gender (odds ratio 
      [OR], 2.73; 95% confidence interval [CI], 1.16-6.41; p < 0.05) and creatinine 
      (Cr) < 50 mumol/L (OR, 2.48; 95% CI, 1.02-5.99; p < 0.05) were significant 
      prognostic factors that predicted relapse. CONCLUSION: A low level of MMP-3 is an 
      excellent positive predictor for PMR with GCA. Among patients with isolated PMR, 
      female gender and Cr < 50 mumol/L were significant prognostic factors that 
      predicted relapse.
FAU - Fukui, Shoichi
AU  - Fukui S
AD  - a Department of Rheumatology , Tokyo Metropolitan Cancer and Infectious Diseases 
      Center Komagome Hospital , Tokyo , Japan.
AD  - c Department of Immunology and Rheumatology , Nagasaki University Graduate School 
      of Biomedical Sciences , Nagasaki , Japan.
FAU - Nunokawa, Takahiro
AU  - Nunokawa T
AD  - b Department of Rheumatology , Tokyo Metropolitan Tama Medical Center , Tokyo , 
      Japan.
FAU - Kobayashi, Satomi
AU  - Kobayashi S
AD  - a Department of Rheumatology , Tokyo Metropolitan Cancer and Infectious Diseases 
      Center Komagome Hospital , Tokyo , Japan.
FAU - Kamei, Satoshi
AU  - Kamei S
AD  - a Department of Rheumatology , Tokyo Metropolitan Cancer and Infectious Diseases 
      Center Komagome Hospital , Tokyo , Japan.
FAU - Yokogawa, Naoto
AU  - Yokogawa N
AD  - b Department of Rheumatology , Tokyo Metropolitan Tama Medical Center , Tokyo , 
      Japan.
FAU - Takizawa, Yasunobu
AU  - Takizawa Y
AD  - a Department of Rheumatology , Tokyo Metropolitan Cancer and Infectious Diseases 
      Center Komagome Hospital , Tokyo , Japan.
FAU - Shimada, Kota
AU  - Shimada K
AD  - b Department of Rheumatology , Tokyo Metropolitan Tama Medical Center , Tokyo , 
      Japan.
FAU - Sugii, Shoji
AU  - Sugii S
AD  - b Department of Rheumatology , Tokyo Metropolitan Tama Medical Center , Tokyo , 
      Japan.
FAU - Setoguchi, Keigo
AU  - Setoguchi K
AD  - a Department of Rheumatology , Tokyo Metropolitan Cancer and Infectious Diseases 
      Center Komagome Hospital , Tokyo , Japan.
LA  - eng
PT  - Journal Article
DEP - 20150819
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Diagnosis, Differential
MH  - Female
MH  - Giant Cell Arteritis/blood/complications/*diagnosis
MH  - Humans
MH  - Japan
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Polymyalgia Rheumatica/blood/complications/*diagnosis
MH  - Prognosis
MH  - Recurrence
MH  - Retrospective Studies
MH  - Sex Factors
OTO - NOTNLM
OT  - Giant cell arteritis
OT  - MMP-3
OT  - Polymyalgia rheumatica
OT  - Predictors
OT  - Prognosis
EDAT- 2015/07/15 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/07/10 06:00
PHST- 2015/07/10 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - 10.3109/14397595.2015.1071304 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2016;26(2):259-64. doi: 10.3109/14397595.2015.1071304. Epub 2015 
      Aug 19.