PMID- 26156202
OWN - NLM
STAT- MEDLINE
DCOM- 20160810
LR  - 20181113
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 57
IP  - 3
DP  - 2015 Nov
TI  - Gene Variant and Level of IL-1beta in Ischemic Stroke Patients With and Without Type 
      2 Diabetes Mellitus.
PG  - 404-9
LID - 10.1007/s12031-015-0614-6 [doi]
AB  - Evidence is emerging that inflammation plays a key role in the pathophysiology of 
      ischemic stroke (IS). The aim of this study was to explore, for the first time, 
      the relationship between IL-1beta -31 T/C polymorphism and the risk of ischemic 
      stroke (IS) among patients with type 2 diabetes mellitus (T2DM). One hundred 
      ninety-six patients with IS (117 diabetics and 79 nondiabetics) and 192 controls 
      were recruited to enroll in this study. IL-1beta genotyping was performed by 
      PCR-RFLP technique. After adjusting for sex, age, smoking, obesity, dyslipidemia, 
      and hypertension, there was no significant difference in the distribution of 
      IL-1beta -31 T/C genotypes and allele frequencies between IS patients with or 
      without type 2 diabetes mellitus and control group (p > 0.05). Moreover, a 
      significant positive correlation between serum IL-1beta level and glucose 
      (p1 = 0.044) was showed. In addition, serum levels of IL-1beta were found to be 
      higher among TT genotype carriers than TC and CC genotype carriers in ischemic 
      stroke patients with or without T2DM but these differences were not significant. 
      These results indicate that IL-1beta gene polymorphism might not be a risk factor in 
      the development of ischemic stroke in Tunisian population.
FAU - Chehaibi, Khouloud
AU  - Chehaibi K
AD  - Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of Medicine, 
      Monastir, 5019, Tunisia. khouloudchehaibi5@gmail.com.
FAU - Hrira, Mohamed Yahia
AU  - Hrira MY
AD  - ResearchUnit: UR 07/06, Faculty of Pharmacy, Monastir, 5019, Tunisia.
FAU - Trabelsi, Imen
AU  - Trabelsi I
AD  - Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of Medicine, 
      Monastir, 5019, Tunisia.
FAU - Escola-Gil, Juan Carlos
AU  - Escola-Gil JC
AD  - Institut d'Investigacions Biomediques (IIB) Sant Pau, Barcelona, Spain.
AD  - CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, 
      Spain.
AD  - Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de 
      Barcelona, Barcelona, Spain.
FAU - Slimane, Mohamed Naceur
AU  - Slimane MN
AD  - Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of Medicine, 
      Monastir, 5019, Tunisia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150709
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Blood Glucose)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Brain Ischemia/blood/epidemiology/*genetics
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Inflammation
MH  - Interleukin-1beta/blood/*genetics
MH  - Lipids/blood
MH  - Lipoproteins/blood
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Smoking/epidemiology
MH  - Tunisia/epidemiology
OTO - NOTNLM
OT  - IL-1beta polymorphism
OT  - Inflammation
OT  - Ischemic stroke
OT  - Type 2 diabetes mellitus
EDAT- 2015/07/15 06:00
MHDA- 2016/08/11 06:00
CRDT- 2015/07/10 06:00
PHST- 2015/05/20 00:00 [received]
PHST- 2015/06/29 00:00 [accepted]
PHST- 2015/07/10 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/08/11 06:00 [medline]
AID - 10.1007/s12031-015-0614-6 [pii]
AID - 10.1007/s12031-015-0614-6 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2015 Nov;57(3):404-9. doi: 10.1007/s12031-015-0614-6. Epub 2015 
      Jul 9.