PMID- 26156527
OWN - NLM
STAT- MEDLINE
DCOM- 20160405
LR  - 20220318
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 38
IP  - 9
DP  - 2015 Sep
TI  - Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease 
      and Reduced Incidence of Type 2 Diabetes.
PG  - 1673-9
LID - 10.2337/dc15-0140 [doi]
AB  - OBJECTIVE: Only a few studies have evaluated the long-term effects of 
      nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and 
      none have examined whether NAFLD improvement reduces T2DM incidence. We 
      investigated the association between NAFLD improvement and T2DM incidence. 
      RESEARCH DESIGN AND METHODS: Between 2000 and 2012, 4,604 participants who 
      underwent a health check twice with >10 years between were enrolled. Exclusion 
      criteria were positive hepatitis B surface antigen, positive hepatitis C 
      antibody, ethanol intake >20 g/day, and diabetes. The 3,074 eligible participants 
      were divided into an NAFLD group (n = 728) and a non-NAFLD group (n = 2,346) 
      according to ultrasonography-detected fatty liver. The NAFLD group was 
      categorized into an improved group (n = 110) and a sustained NAFLD group (n = 
      618) based on fatty liver disappearance at the second visit. Incident T2DM odds 
      ratios (ORs) were estimated by logistic regression models adjusted for age, sex, 
      BMI, impaired fasting glucose, family history of diabetes, dyslipidemia, 
      hypertension, and physical exercise. RESULTS: T2DM occurred in 117 participants 
      (16.1%) in the NAFLD group and 72 (3.1%) in the non-NAFLD group. NAFLD at 
      baseline was associated with T2DM incidence (multivariate OR 2.37 [95% CI 
      1.60-3.52]). T2DM occurred in 7 participants (6.4%) in the improved group and in 
      110 (17.8%) in the sustained NAFLD group. NAFLD improvement was associated with 
      reduced T2DM incidence (multivariate OR 0.27 [95% CI 0.12-0.61]). CONCLUSIONS: 
      NAFLD improvement is associated with T2DM incidence reduction.
CI  - (c) 2015 by the American Diabetes Association. Readers may use this article as long 
      as the work is properly cited, the use is educational and not for profit, and the 
      work is not altered.
FAU - Yamazaki, Hajime
AU  - Yamazaki H
AUID- ORCID: 0000-0002-9034-4370
AD  - Center for Gastroenterology, Teine Keijinkai Hospital, Sapporo, Japan 
      yamazaki-myz@umin.ac.jp.
FAU - Tsuboya, Toru
AU  - Tsuboya T
AD  - Department of Social and Behavioral Sciences, Harvard School of Public Health, 
      Boston, MA Department of International and Community Oral Health, Tohoku 
      University Graduate School of Dentistry, Sendai, Japan.
FAU - Tsuji, Kunihiko
AU  - Tsuji K
AD  - Center for Gastroenterology, Teine Keijinkai Hospital, Sapporo, Japan.
FAU - Dohke, Mitsuru
AU  - Dohke M
AD  - Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, 
      Japan.
FAU - Maguchi, Hiroyuki
AU  - Maguchi H
AD  - Center for Gastroenterology, Teine Keijinkai Hospital, Sapporo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150708
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Adult
MH  - Aged
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Dyslipidemias/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*epidemiology/*prevention & control
MH  - Odds Ratio
MH  - Prediabetic State/epidemiology
MH  - Risk Factors
EDAT- 2015/07/15 06:00
MHDA- 2016/04/06 06:00
CRDT- 2015/07/10 06:00
PHST- 2015/01/20 00:00 [received]
PHST- 2015/06/15 00:00 [accepted]
PHST- 2015/07/10 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/04/06 06:00 [medline]
AID - dc15-0140 [pii]
AID - 10.2337/dc15-0140 [doi]
PST - ppublish
SO  - Diabetes Care. 2015 Sep;38(9):1673-9. doi: 10.2337/dc15-0140. Epub 2015 Jul 8.