PMID- 26156560
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20170227
IS  - 1541-1087 (Electronic)
IS  - 0731-5724 (Linking)
VI  - 35
IP  - 5
DP  - 2016 Jul
TI  - Effects of Vitamin K on Matrix Metalloproteinase-3 and Rheumatoid Factor in Women 
      with Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled Trial.
PG  - 392-8
LID - 10.1080/07315724.2015.1026004 [doi]
AB  - OBJECTIVES: Rheumatoid arthritis (RA) is an autoimmune disease characterized by 
      an increase in some autoantibodies and proteolytic enzymes, leading to joint 
      destruction. Although recent investigations have considered vitamin K as an 
      anti-inflammatory nutrient with an important role in bone metabolism, there is 
      currently limited information on its efficacy in RA. We aimed to examine the 
      effects of vitamin K1 (phylloquinone) on the biomarker of joint destruction and 
      autoantibody in patients with RA. MATERIALS AND METHODS: This was a randomized 
      clinical trial in which 64 women with RA who fulfilled the eligibility criteria 
      were randomly allocated to an intervention or a control group. Vitamin K1 or 
      placebo was administered to the participants for 8 weeks. Baseline 
      characteristics and anthropometric measures were obtained. Clinical status using 
      disease activity score in 28 joints (DAS-28), serum levels of matrix 
      metalloproteinase-3 (MMP-3), and rheumatoid factor (RF) were assessed before and 
      after the intervention. RESULTS: The serum level of MMP-3 compared with the 
      baseline values did not change significantly in the groups. However, the serum 
      concentration of RF decreased significantly in the vitamin K1 group (p = 0.041). 
      Intergroup comparison showed no significant change in RF serum level after 
      adjusting for relevant confounders (p > 0.05). CONCLUSIONS: Vitamin K1 
      supplementation at 10 mg/day for 8 weeks did not alter joint destruction and 
      immune status in the patients with RA compared with the controls.
FAU - Shishavan, Neda Ghamarzad
AU  - Shishavan NG
AD  - a Department of Biochemistry and Diet Therapy, Nutrition Research Center, Faculty 
      of Nutrition , Tabriz University of Medical Sciences , Tabriz , IRAN.
AD  - b Student Research Committee , Tabriz University of Medical Sciences , Tabriz , 
      IRAN.
FAU - Gargari, Bahram Pourghassem
AU  - Gargari BP
AD  - a Department of Biochemistry and Diet Therapy, Nutrition Research Center, Faculty 
      of Nutrition , Tabriz University of Medical Sciences , Tabriz , IRAN.
FAU - Kolahi, Sousan
AU  - Kolahi S
AD  - c Department of Rheumatology, Connective Tissue Diseases Research Center, Faculty 
      of Medicine , Tabriz University of Medical Sciences , Tabriz , IRAN.
FAU - Hajialilo, Mehrzad
AU  - Hajialilo M
AD  - c Department of Rheumatology, Connective Tissue Diseases Research Center, Faculty 
      of Medicine , Tabriz University of Medical Sciences , Tabriz , IRAN.
FAU - Jafarabadi, Mohammad Asghari
AU  - Jafarabadi MA
AD  - d Department of Statistics and Epidemiology, Faculty of Health , Tabriz 
      University of Medical Sciences , Tabriz , IRAN.
FAU - Javadzadeh, Yousef
AU  - Javadzadeh Y
AD  - e School of Pharmacy, Tabriz University of Medical Sciences , Tabriz , IRAN.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150709
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Biomarkers)
RN  - 0 (Placebos)
RN  - 84-80-0 (Vitamin K 1)
RN  - 9009-79-4 (Rheumatoid Factor)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/*blood/*drug therapy/physiopathology
MH  - Biomarkers/blood
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Joints/physiopathology
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Placebos
MH  - Rheumatoid Factor/*blood
MH  - Vitamin K 1/administration & dosage/*therapeutic use
OTO - NOTNLM
OT  - matrix metalloproteinase-3
OT  - phylloquinone
OT  - rheumatoid arthritis
OT  - rheumatoid factor
OT  - vitamin K
EDAT- 2015/07/15 06:00
MHDA- 2017/02/28 06:00
CRDT- 2015/07/10 06:00
PHST- 2015/07/10 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
AID - 10.1080/07315724.2015.1026004 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 2016 Jul;35(5):392-8. doi: 10.1080/07315724.2015.1026004. Epub 
      2015 Jul 9.