PMID- 26157640
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150709
LR  - 20220129
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 3
DP  - 2015
TI  - Mice that gorged during dietary restriction increased foraging related behaviors 
      and differed in their macronutrient preference when released from restriction.
PG  - e1091
LID - 10.7717/peerj.1091 [doi]
LID - e1091
AB  - Caloric restriction (CR) can trigger gorging behavior. We examined macronutrient 
      choice and behavior in mice that gorged during restriction compared to restricted 
      non-gorgers and controls. Fifty MF1 male mice were restricted to 75% of 
      ad-libitum food intake (FI), while ten controls were fed ad-lib. Body mass (BM) 
      and FI were measured two and 24-h after food inclusion over 14-days. 'Gorging' 
      mice were defined as those which ate over 25% of their daily FI in 2-h. The top 
      11 gorgers and the lowest 9 gorgers, along with 10 controls, had their behavior 
      analysed during restriction, and were then provided with an unrestricted food 
      choice, consisting of three diets that were high in fat, protein or carbohydrate. 
      During restriction gorgers ate on average 51% of their daily FI in the 2-h 
      following food introduction while the non-gorgers ate only 16%. Gorgers lost 
      significantly more BM than non-gorgers possibly due to an increased physical 
      activity linked to anticipation of daily food provision. Controls and non-gorgers 
      spent most of their time sleeping. After restriction, both gorgers and 
      non-gorgers were hyperphagic until their lost weight was regained. All 3 groups 
      favoured high fat food. Gorgers and non-gorgers had a significantly greater high 
      carbohydrate diet intake than controls, and gorgers also had a significantly 
      greater high protein diet intake than non-gorgers and controls. On unrestricted 
      food, they did not continue to gorge, although they still had a significantly 
      greater 2-h FI than the other groups. Elevated protein intake may play an 
      important role in the recovery of the lost lean tissue of gorgers after 
      restriction.
FAU - Hambly, Catherine
AU  - Hambly C
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen , 
      Aberdeen , UK.
FAU - Speakman, John R
AU  - Speakman JR
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen , 
      Aberdeen , UK ; Institute of Genetics and Developmental Biology, Chinese Academy 
      of Sciences , Beijing , China.
LA  - eng
GR  - BB/G009953/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
DEP - 20150702
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC4493644
OTO - NOTNLM
OT  - Activity
OT  - Diet choice
OT  - Food restriction
OT  - Gorging
OT  - Macronutrient
COIS- The authors declare there are no competing interests.
EDAT- 2015/07/15 06:00
MHDA- 2015/07/15 06:01
PMCR- 2015/07/02
CRDT- 2015/07/10 06:00
PHST- 2015/04/25 00:00 [received]
PHST- 2015/06/17 00:00 [accepted]
PHST- 2015/07/10 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/07/15 06:01 [medline]
PHST- 2015/07/02 00:00 [pmc-release]
AID - 1091 [pii]
AID - 10.7717/peerj.1091 [doi]
PST - epublish
SO  - PeerJ. 2015 Jul 2;3:e1091. doi: 10.7717/peerj.1091. eCollection 2015.