PMID- 26158223
OWN - NLM
STAT- MEDLINE
DCOM- 20160310
LR  - 20220317
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 6
IP  - 8
DP  - 2015 Aug
TI  - Effect of 5-caffeoylquinic acid on the NF-kappaB signaling pathway, peroxisome 
      proliferator-activated receptor gamma 2, and macrophage infiltration in high-fat 
      diet-fed Sprague-Dawley rat adipose tissue.
PG  - 2779-86
LID - 10.1039/c5fo00626k [doi]
AB  - Obesity, considered as a consequence of overnutrition, sustains a low-degree 
      inflammatory state and results in insulin-resistance and type 2 diabetes. Here, 
      we investigated the anti-inflammatory effects of 5-caffeoylquinic acid (5-CQA) in 
      high-fat diet-induced obese rats. Serum interleukin (IL)-6, monocyte chemotactic 
      protein 1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), total cholesterol (TC), 
      triglyceride (TG), and free fatty acid (FFA) levels were determined. Expression 
      of genes related to TG metabolism, macrophage biomarkers, and inflammation was 
      assessed by real-time PCR. Protein expression of NF-kappaB, PPARgamma2, and 
      phosphorylated IkappaBalpha was evaluated by western blotting, and the histology of 
      adipose tissue was examined. Supplementation of the rat diet with 5-CQA reduced 
      obesity development, macrophage infiltration, and steatosis. Additionally, 5-CQA 
      decreased the expression of NF-kappaB and downstream inflammatory cytokines, but 
      increased the expression of PPARgamma2, in a dose-dependent manner. Thus, 5-CQA 
      improved obesity and obesity-related metabolic disturbances via PPARgamma2 and the 
      NF-kappaB signaling pathway.
FAU - Liu, Si-Le
AU  - Liu SL
AD  - College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, 
      Hunan 410128, China. wz8918@163.com.
FAU - Peng, Bing-Jie
AU  - Peng BJ
FAU - Zhong, Ying-Li
AU  - Zhong YL
FAU - Liu, Yun-Long
AU  - Liu YL
FAU - Song, Zhuo
AU  - Song Z
FAU - Wang, Zheng
AU  - Wang Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150709
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (NF-kappa B)
RN  - 0 (PPAR gamma)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (caffeoylquinic acid)
RN  - 058C04BGYI (Quinic Acid)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adipose Tissue/*drug effects/enzymology/immunology
MH  - Animals
MH  - Chemokine CCL2/blood
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/genetics/immunology
MH  - Humans
MH  - Macrophages/*drug effects/immunology
MH  - Male
MH  - NF-kappa B/genetics/*immunology
MH  - PPAR gamma/genetics/*immunology
MH  - Quinic Acid/administration & dosage/*analogs & derivatives
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2015/07/15 06:00
MHDA- 2016/03/11 06:00
CRDT- 2015/07/10 06:00
PHST- 2015/07/10 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/03/11 06:00 [medline]
AID - 10.1039/c5fo00626k [doi]
PST - ppublish
SO  - Food Funct. 2015 Aug;6(8):2779-86. doi: 10.1039/c5fo00626k. Epub 2015 Jul 9.