PMID- 26158358
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20220310
IS  - 1087-2108 (Electronic)
IS  - 1087-2108 (Linking)
VI  - 21
IP  - 6
DP  - 2015 Jun 16
TI  - Defining intrinsic vs. extrinsic atopic dermatitis.
LID - 13030/qt14p8p404 [pii]
AB  - Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition 
      characterized by eczematous lesions, i.e. ill-demarcated erythematous patches and 
      plaques. AD is commonly associated with elevated immunoglobulin E (IgE) and 
      atopic disorders, such as asthma, hay fever, and food allergies. Rackemann and 
      Mallory were some of the first to distinguish between asthma based on the 
      presence ("extrinsic") or absence ("intrinsic") of allergy. This distinction has 
      subsequently been applied to AD based on the presence ("extrinsic") or absence 
      ("intrinsic") of increased IgE and atopic disease. Although the distinction 
      between intrinsic and extrinsic AD is widely used, it remains controversial.
FAU - Karimkhani, Chante
AU  - Karimkhani C
AD  - Columbia University College of Physicians and Surgeons.
FAU - Silverberg, Jonathan I
AU  - Silverberg JI
FAU - Dellavalle, Robert P
AU  - Dellavalle RP
LA  - eng
PT  - Journal Article
DEP - 20150616
PL  - United States
TA  - Dermatol Online J
JT  - Dermatology online journal
JID - 9610776
RN  - 0 (Filaggrin Proteins)
RN  - 0 (Intermediate Filament Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/immunology
MH  - Dermatitis, Atopic/classification/*genetics/*immunology
MH  - Filaggrin Proteins
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Intermediate Filament Proteins/genetics
MH  - *Phenotype
MH  - Severity of Illness Index
MH  - Skin Physiological Phenomena/genetics
EDAT- 2015/07/15 06:00
MHDA- 2016/04/09 06:00
CRDT- 2015/07/10 06:00
PHST- 2015/06/15 00:00 [received]
PHST- 2015/06/15 00:00 [accepted]
PHST- 2015/07/10 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
AID - 13030/qt14p8p404 [pii]
PST - epublish
SO  - Dermatol Online J. 2015 Jun 16;21(6):13030/qt14p8p404.