PMID- 26160323
OWN - NLM
STAT- MEDLINE
DCOM- 20160620
LR  - 20240213
IS  - 1873-4626 (Electronic)
IS  - 1091-255X (Print)
IS  - 1091-255X (Linking)
VI  - 19
IP  - 11
DP  - 2015 Nov
TI  - Intraductal Papillary Mucinous Neoplasms and the Risk of Diabetes Mellitus in 
      Patients Undergoing Resection Versus Observation.
PG  - 1974-81
LID - 10.1007/s11605-015-2885-1 [doi]
AB  - OBJECTIVE: The aim of this study is to determine the prevalence of diabetes 
      mellitus (DM) in patients with intraductal papillary mucinous neoplasm of the 
      pancreas (IPMN) and compare rates of new/progressive DM between IPMN patients 
      undergoing pancreatectomy versus observation. METHODS: Patients diagnosed with 
      IPMN were identified from institutional databases, divided into two groups based 
      on treatment type, pancreatectomy versus clinical observation, and subsequently 
      evaluated. Standard demographic and clinicopathologic variables, fasting glucose, 
      diabetic status, and pancreatic volume data, were obtained and compared between 
      groups. RESULTS: One hundred thirty-four IPMN patients were identified; 103 (77 
      %) underwent pancreatectomy and 31 (23 %) were observed. Baseline DM rate was 18 
      % (24/134). This was not different between groups [17 % (17/103) resected vs. 23 
      % (7/31) observed, p = 0.51]. Median follow-up was 53 months and new/progressive 
      DM occurred in 37 (28 %) patients with no difference between groups [29 (28 %) 
      resected vs. 8 (26 %) observed, p = 0.74]. Among resected patients, degree of 
      dysplasia was associated with increase risk of new/progressive DM [moderate 
      dysplasia OR 5.76 (1.24-26.79) and severe dysplasia OR 9.43 (1.54-57.74), 
      p = 0.04], while procedure type and remnant volume were not. CONCLUSIONS: The 
      incidence and prevalence of DM among patients with IPMN was high and did not 
      differ between resected and observed groups. Degree of dysplasia, not the amount 
      of resected pancreas, was associated with increased risk of DM, suggesting that 
      the presence or development of DM may be a marker of malignant progression. 
      Confirmatory studies are required.
FAU - Leal, Julie N
AU  - Leal JN
AD  - Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 
      10065, USA.
FAU - Kingham, T Peter
AU  - Kingham TP
AD  - Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 
      10065, USA.
FAU - D'Angelica, Michael I
AU  - D'Angelica MI
AD  - Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 
      10065, USA.
FAU - DeMatteo, Ronald P
AU  - DeMatteo RP
AD  - Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 
      10065, USA.
FAU - Jarnagin, William R
AU  - Jarnagin WR
AD  - Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 
      10065, USA.
FAU - Kalin, Marcia F
AU  - Kalin MF
AD  - Department of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, 
      NY, 10065, USA.
FAU - Allen, Peter J
AU  - Allen PJ
AD  - Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 
      10065, USA. allenp@mskcc.org.
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
DEP - 20150710
PL  - Netherlands
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery 
      of the Alimentary Tract
JID - 9706084
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Pancreatic Ductal/pathology/*surgery
MH  - Diabetes Mellitus/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pancreatectomy
MH  - Pancreatic Neoplasms/pathology/*surgery
MH  - Prevalence
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - *Watchful Waiting
PMC - PMC4809678
MID - NIHMS769003
OTO - NOTNLM
OT  - Intraductal papillary mucinous neoplasm (IPMN)
OT  - Pancreatectomy
OT  - Surveillance and diabetes mellitus
COIS- Conflict of Interest The authors declare that they have no competing interests.
EDAT- 2015/07/15 06:00
MHDA- 2016/06/21 06:00
PMCR- 2016/11/01
CRDT- 2015/07/11 06:00
PHST- 2015/05/12 00:00 [received]
PHST- 2015/06/23 00:00 [accepted]
PHST- 2015/07/11 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/06/21 06:00 [medline]
PHST- 2016/11/01 00:00 [pmc-release]
AID - S1091-255X(23)07398-5 [pii]
AID - 10.1007/s11605-015-2885-1 [doi]
PST - ppublish
SO  - J Gastrointest Surg. 2015 Nov;19(11):1974-81. doi: 10.1007/s11605-015-2885-1. 
      Epub 2015 Jul 10.