PMID- 26161003
OWN - NLM
STAT- MEDLINE
DCOM- 20160527
LR  - 20191210
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2015
DP  - 2015
TI  - Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in 
      Women.
PG  - 516783
LID - 10.1155/2015/516783 [doi]
LID - 516783
AB  - BACKGROUND: Since high sensitivity C-reactive protein (hsCRP) is predictive of 
      cardiovascular events, it is important to examine the relationship between hsCRP 
      and other inflammatory and oxidative stress markers linked to cardiovascular 
      disease (CVD) etiology. Previously, we reported that hsCRP induces the oxidative 
      stress adduct 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxodG) and that these markers 
      are significantly associated in women. Recent data indicates that brain-derived 
      neurotrophic factor (BDNF) may have a role in CVD. METHODS AND RESULTS: We 
      examined BDNF levels in 3 groups of women that were age- and race-matched with 
      low (<3 mg/L), mid (>3-20 mg/L), and high (>20 mg/L) hsCRP (n = 39 per group) and 
      found a significant association between hsCRP, BDNF, and 8-oxodG. In African 
      American females with high hsCRP, increases in BDNF were associated with 
      decreased serum 8-oxodG. This was not the case in white women where high hsCRP 
      was associated with high levels of BDNF and high levels of 8-oxodG. BDNF 
      treatment of cells reduced CRP levels and inhibited CRP-induced DNA damage. 
      CONCLUSION: We discovered an important relationship between hsCRP, 8-oxodG, and 
      BDNF in women at hsCRP levels >3 mg/L. These data suggest that BDNF may have a 
      protective role in counteracting the inflammatory effects of hsCRP.
FAU - Noren Hooten, Nicole
AU  - Noren Hooten N
AD  - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, 
      National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
FAU - Ejiogu, Ngozi
AU  - Ejiogu N
AD  - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, 
      National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
FAU - Zonderman, Alan B
AU  - Zonderman AB
AD  - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, 
      National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
FAU - Evans, Michele K
AU  - Evans MK
AD  - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, 
      National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150526
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Adult
MH  - Blood Pressure
MH  - Brain-Derived Neurotrophic Factor/blood/*physiology
MH  - C-Reactive Protein/analysis/*physiology
MH  - Cells, Cultured
MH  - Deoxyguanosine/analogs & derivatives/blood
MH  - Female
MH  - Humans
MH  - Inflammation/*prevention & control
MH  - Middle Aged
PMC - PMC4460236
EDAT- 2015/07/15 06:00
MHDA- 2016/05/28 06:00
PMCR- 2015/05/26
CRDT- 2015/07/11 06:00
PHST- 2015/03/13 00:00 [received]
PHST- 2015/05/11 00:00 [revised]
PHST- 2015/05/14 00:00 [accepted]
PHST- 2015/07/11 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/05/28 06:00 [medline]
PHST- 2015/05/26 00:00 [pmc-release]
AID - 10.1155/2015/516783 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2015;2015:516783. doi: 10.1155/2015/516783. Epub 2015 May 26.