PMID- 26162860
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20181202
IS  - 1203-4754 (Print)
IS  - 1203-4754 (Linking)
VI  - 20
IP  - 1
DP  - 2016 Jan
TI  - Cutaneous Adverse Events in Chronic Hepatitis C Patients Treated With New 
      Direct-Acting Antivirals: A Systematic Review and Meta-Analysis.
PG  - 58-66
LID - 10.1177/1203475415595775 [doi]
AB  - BACKGROUND: Direct-acting antivirals (DAAs) are known to present with additional 
      dermatological events over pegylated-interferon/ribavirin (Peg-IFN/RBV). 
      OBJECTIVE: A systematic review and meta-analysis was conducted to assess the 
      incidence/risk of cutaneous adverse events (AEs) for simeprevir, sofosbuvir, 
      ABT450/r-ombitasvir, dasabuvir, ledipasvir, daclatasvir, and asunaprevir. 
      METHODS: The databases searched included PubMed, Clinicaltrials.gov, and 
      Clinicaloptions.com. Data on telaprevir and boceprevir were obtained from a 
      previous study. RESULTS: The incidences of cutaneous AEs were 34.3% (95% CI 
      18.4%-54.8%) for the old DAAs + Peg-IFN/RBV, 22.0% (95% CI 17.9%-26.8%) for the 
      new DAAs + Peg-IFN/RBV, 9.8% (95% CI 8.6%-11.2%) for the DAAs + RBV, and 3.8% 
      (95% CI 2.4%-6.1%) for DAAs only. Simeprevir + Peg-IFN/RBV was associated with an 
      increased relative risk over Peg-IFN/RBV; RR = 1.319 (95% CI 1.026-1.697). 
      CONCLUSION: Dermatological events are still an important issue for many of the 
      new DAAs. Appropriate monitoring, management, and patient education are needed to 
      minimize AEs and achieve HCV cure.
CI  - (c) The Author(s) 2015.
FAU - Patel, Parth
AU  - Patel P
AD  - Department of Medicine, Division of Dermatology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
FAU - Malik, Kunal
AU  - Malik K
AD  - College of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
FAU - Krishnamurthy, Karthik
AU  - Krishnamurthy K
AD  - Department of Medicine, Division of Dermatology, Albert Einstein College of 
      Medicine, Bronx, NY, USA kkderm@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20150710
PL  - United States
TA  - J Cutan Med Surg
JT  - Journal of cutaneous medicine and surgery
JID - 9614685
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - Antiviral Agents/*adverse effects
MH  - Hepatitis C, Chronic/*drug therapy
MH  - Humans
MH  - Skin Diseases/*chemically induced
OTO - NOTNLM
OT  - dermatitis
OT  - dermatology
OT  - immunology
OT  - infectious disease
EDAT- 2015/07/15 06:00
MHDA- 2017/04/30 06:00
CRDT- 2015/07/12 06:00
PHST- 2015/07/12 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
AID - 1203475415595775 [pii]
AID - 10.1177/1203475415595775 [doi]
PST - ppublish
SO  - J Cutan Med Surg. 2016 Jan;20(1):58-66. doi: 10.1177/1203475415595775. Epub 2015 
      Jul 10.