PMID- 26163051
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20181202
IS  - 1744-8344 (Electronic)
IS  - 1477-9072 (Linking)
VI  - 13
IP  - 8
DP  - 2015
TI  - The management of patients with aortic regurgitation and severe left ventricular 
      dysfunction: a systematic review.
PG  - 915-22
LID - 10.1586/14779072.2015.1067139 [doi]
AB  - A systematic search of Medline, EMBASE and CINAHL electronic databases was 
      performed. Original research articles reporting all-cause mortality following 
      surgery in patients with aortic regurgitation and severe left ventricular 
      systolic dysfunction (LVSD) were identified. Nine of the 10 eligible studies were 
      observational, single-center, retrospective analyses. Survival ranged from 86 to 
      100% at 30 days; 81 to 100% at 1 year and 68 to 84% at 5 years. Three studies 
      described an improvement in mean left ventricular ejection fraction (LVEF) 
      following aortic valve replacement (AVR) of 5-14%; a fourth study reported an 
      increase in mean left ventricular ejection fraction (LVEF) of 9% in patients 
      undergoing isolated AVR but not when AVR was combined with coronary artery bypass 
      graft and/or mitral valve surgery. Three studies demonstrated improvements in 
      functional New York Heart Association (NYHA) class following AVR. Additional 
      studies are needed to clarify the benefits of AVR in patients with more extreme 
      degrees of left ventricular systolic dysfunction (LVSD) and the potential roles 
      of cardiac transplantation and transaortic valve implantation.
FAU - Badar, Athar A
AU  - Badar AA
AD  - University of Glasgow, Glasgow, UK.
FAU - Brunton, Alan P T
AU  - Brunton AP
FAU - Mahmood, Ammad H
AU  - Mahmood AH
FAU - Dobbin, Stephen
AU  - Dobbin S
FAU - Pozzi, Andrea
AU  - Pozzi A
FAU - McMinn, Jenna F
AU  - McMinn JF
FAU - Sinclair, Andrew J E
AU  - Sinclair AJ
FAU - Gardner, Roy S
AU  - Gardner RS
FAU - Petrie, Mark C
AU  - Petrie MC
FAU - Curry, Phil A
AU  - Curry PA
FAU - Al-Attar, Nawwar H K
AU  - Al-Attar NH
FAU - Pettit, Stephen J
AU  - Pettit SJ
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20150710
PL  - England
TA  - Expert Rev Cardiovasc Ther
JT  - Expert review of cardiovascular therapy
JID - 101182328
SB  - IM
MH  - Aortic Valve Insufficiency/complications/*therapy
MH  - Humans
MH  - Retrospective Studies
MH  - Ventricular Dysfunction, Left/complications/*therapy
OTO - NOTNLM
OT  - aortic regurgitation
OT  - aortic valve replacement
OT  - cardiac transplantation
OT  - left ventricular dysfunction
OT  - transcatheter aortic valve replacement
OT  - valvular heart disease
EDAT- 2015/07/15 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/07/12 06:00
PHST- 2015/07/12 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - 10.1586/14779072.2015.1067139 [doi]
PST - ppublish
SO  - Expert Rev Cardiovasc Ther. 2015;13(8):915-22. doi: 
      10.1586/14779072.2015.1067139. Epub 2015 Jul 10.