PMID- 26163152
OWN - NLM
STAT- MEDLINE
DCOM- 20160328
LR  - 20181202
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 73
DP  - 2015 Jul
TI  - Environmental prenatal stress eliminates brain and maternal behavioral sex 
      differences and alters hormone levels in female rats.
PG  - 142-7
LID - S0018-506X(15)30015-5 [pii]
LID - 10.1016/j.yhbeh.2015.07.004 [doi]
AB  - Environmental prenatal stress (EPS) has effects on fetuses that are long-lasting, 
      altering their hormone levels, brain morphology and behavior when they reach 
      maturity. In previous research, we demonstrated that EPS affects the expression 
      of induced maternal behavior (MB), the neuroendocrine system, and morphology of 
      the sexually dimorphic accessory olfactory bulb (AOB) involved in reproductive 
      behavior patterns. The bed nucleus of the accessory olfactory tract (BAOT) is 
      another vomeronasal (VN) structure that plays an inhibitory role in rats in the 
      expression of induced maternal behavior in female and male virgins. In the 
      present study, we have ascertained whether the behavioral, neuroendocrine, and 
      neuromorphological alterations of the AOB found after EPS also appear in the 
      BAOT. After applying EPS to pregnant rats during the late gestational period, in 
      their female offspring at maturity we tested induced maternal behavior, BAOT 
      morphology and plasma levels of testosterone (T), estradiol (E2), progesterone 
      (P), adrenocorticotropic hormone (ACTH) and corticosterone (Cpd B). EPS: a) 
      affected the induction of MB, showed a male-like pattern of care for pups, b) 
      elevated plasma levels of Cpd B and reduced E2 in comparison with the controls, 
      and c) significantly increased the number of BAOT neurons compared to the control 
      females and comparable to the control male group. These findings provide further 
      evidence that stress applied to pregnant rats produces long-lasting behavioral, 
      endocrine and neuroanatomical alterations in the female offspring that are 
      evident when they become mature.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Del Cerro, M C R
AU  - Del Cerro MC
AD  - Departamento de Psicobiologia, Universidad Nacional de Educacion a Distancia C/ 
      Juan del Rosal 10, 28040 Madrid, Spain. Electronic address: 
      mcrdelcerro@psi.uned.es.
FAU - Ortega, E
AU  - Ortega E
AD  - Departamento de Bioquimica y Biologia Molecular, Avda. de Madrid s/n degrees , Granada, 
      Spain.
FAU - Gomez, F
AU  - Gomez F
AD  - Centro de Salud Joaquin Rodrigo, Servicio Madrileno de Salud, Area 11 AP, Madrid, 
      Spain.
FAU - Segovia, S
AU  - Segovia S
AD  - Departamento de Psicobiologia, Universidad Nacional de Educacion a Distancia C/ 
      Juan del Rosal 10, 28040 Madrid, Spain.
FAU - Perez-Laso, C
AU  - Perez-Laso C
AD  - Departamento de Psicobiologia, Universidad Nacional de Educacion a Distancia C/ 
      Juan del Rosal 10, 28040 Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150707
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 3XMK78S47O (Testosterone)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Brain/*physiology
MH  - Corticosterone/blood
MH  - Estradiol/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Maternal Behavior/*physiology
MH  - Olfactory Bulb/physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/blood/*psychology
MH  - Progesterone/blood
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Characteristics
MH  - Sexual Behavior/psychology
MH  - Stress, Psychological/*physiopathology/psychology
MH  - Testosterone/blood
OTO - NOTNLM
OT  - ACTH
OT  - Bed nucleus of the accessory olfactory tract
OT  - Brain development
OT  - Corticosterone
OT  - Environmental prenatal stress
OT  - Estradiol
OT  - Maternal behavior
OT  - Progesterone
OT  - Rats
OT  - Testosterone
EDAT- 2015/07/15 06:00
MHDA- 2016/03/29 06:00
CRDT- 2015/07/12 06:00
PHST- 2015/01/20 00:00 [received]
PHST- 2015/06/29 00:00 [revised]
PHST- 2015/07/02 00:00 [accepted]
PHST- 2015/07/12 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/03/29 06:00 [medline]
AID - S0018-506X(15)30015-5 [pii]
AID - 10.1016/j.yhbeh.2015.07.004 [doi]
PST - ppublish
SO  - Horm Behav. 2015 Jul;73:142-7. doi: 10.1016/j.yhbeh.2015.07.004. Epub 2015 Jul 7.