PMID- 26163620
OWN - NLM
STAT- MEDLINE
DCOM- 20160404
LR  - 20191210
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 16
IP  - 12
DP  - 2015
TI  - Implications of Sex Hormone Receptor Gene Expression in the Predominance of 
      Hepatocellular Carcinoma in Males: Role of Natural Products.
PG  - 4949-54
AB  - The present study was planned to investigate the role of sex hormone receptor 
      gene expression in the pathogenesis of hepatocellular carcinoma (HCC). Adult male 
      Wistar rats were divided into seven groups. Group (1) was negative control. 
      Groups (2), (5), (6), and (7) were orally administered with N-nitrosodiethylamine 
      for the induction of HCC, then group (2) was left untreated, group (5) was orally 
      treated with curcumin, group (6) was orally treated with carvacrol, and group (7) 
      was intraperitoneally injected with doxorubicin, whereas groups (3) and (4) were 
      orally administered only curcumin and carvacrol, respectively. The HCC group 
      showed significant upregulation in the androgen receptor (AR) and the estrogen 
      receptor-alpha (ERalpha) gene expression levels in the liver tissue. On the contrary, 
      HCC groups treated with either curcumin or carvacrol showed significant 
      downregulation in AR and ERalpha gene expression levels in the liver tissue. In 
      conclusion, the obtained data highlight that both AR and ERalpha but not estrogen 
      receptor-beta (ERbeta) gene expression may contribute to the male prevalence of HCC 
      induced in male rats. Interestingly, both curcumin and carvacrol were found to 
      have a promising potency in alleviating the male predominating HCC.
FAU - Ahmed, Hanaa H
AU  - Ahmed HH
AD  - Hormones Department, Medical Research Division, National Research Centre, Dokki, 
      Giza, Egypt E-mail : Hanaaomr@yahoo.com.
FAU - Shousha, Wafaa Gh
AU  - Shousha WG
FAU - Shalby, Aziza B
AU  - Shalby AB
FAU - El-Mezayen, Hatem A
AU  - El-Mezayen HA
FAU - Ismaiel, Nora N
AU  - Ismaiel NN
FAU - Mahmoud, Nadia S
AU  - Mahmoud NS
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biological Products)
RN  - 0 (Cymenes)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Monoterpenes)
RN  - 0 (Receptors, Androgen)
RN  - 3IQ78TTX1A (Diethylnitrosamine)
RN  - 9B1J4V995Q (carvacrol)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Biological Products/*pharmacology
MH  - Carcinoma, Hepatocellular/*drug therapy/genetics
MH  - Curcumin/pharmacology
MH  - Cymenes
MH  - Diethylnitrosamine/pharmacology
MH  - Down-Regulation/drug effects/genetics
MH  - Estrogen Receptor alpha/*genetics
MH  - Estrogen Receptor beta/*genetics
MH  - Gene Expression/*drug effects/genetics
MH  - Gonadal Steroid Hormones/*genetics
MH  - Liver Neoplasms/*drug therapy/genetics
MH  - Male
MH  - Monoterpenes/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Androgen/genetics
MH  - Up-Regulation/drug effects/genetics
EDAT- 2015/07/15 06:00
MHDA- 2016/04/05 06:00
CRDT- 2015/07/12 06:00
PHST- 2015/07/12 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2016/04/05 06:00 [medline]
AID - 10.7314/apjcp.2015.16.12.4949 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2015;16(12):4949-54. doi: 10.7314/apjcp.2015.16.12.4949.