PMID- 26164865
OWN - NLM
STAT- MEDLINE
DCOM- 20151013
LR  - 20150803
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 350
IP  - 2
DP  - 2015 Aug
TI  - Free triiodothyronine levels and short-term prognosis in chronic heart failure 
      patients with type 2 diabetes.
PG  - 87-94
LID - 10.1097/MAJ.0000000000000524 [doi]
AB  - BACKGROUND: In chronic heart failure (CHF) patients with type 2 diabetes mellitus 
      (T2DM), the role of thyroid hormone (TH) in predicting CHF severity and prognosis 
      is unclear. The authors therefore investigated the role of TH in predicting CHF 
      severity and prognosis in these specific patients. METHODS: A total of 224 CHF 
      patients (114 with T2DM) over a mean follow-up time of 6.56 +/- 0.18 months were 
      studied. TH, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other 
      parameters were measured. RESULTS: Free triiodothyronine (FT3) levels were lower 
      in the T2DM group compared with the nondiabetes group (P = 0.026) and higher in 
      the New York Heart Association (NYHA) I group than in the NYHA III and IV groups 
      (both P < 0.05). Compared with the low NT-proBNP group, the high NT-proBNP group 
      had lower FT3 levels (P < 0.01). NT-proBNP correlated with NYHA classes (r = 
      0.541, P < 0.001), and inversely correlated with left ventricular ejection 
      fraction (r = -0.431, P < 0.001) and FT3 levels (r = -0.335, P < 0.001). In 
      multiple linear regression analysis, NT-proBNP was significantly correlated with 
      NYHA classes (P < 0.001), left ventricular ejection fraction (P < 0.001) and FT3 
      (P = 0.004). Kaplan-Meier curves showed that the low FT3 group had an increased 
      rate of short-term adverse outcomes of CHF (log rank, chi = 9.794, P = 0.002). 
      CONCLUSIONS: FT3 levels are associated with the severity of CHF and seem to 
      reflect short-term outcomes in CHF patients with T2DM.
FAU - Chen, Pingan
AU  - Chen P
AD  - Department of Cardiology (P-AC, S-NL, X-ML, ZL, YL), Guangzhou First People's 
      Hospital, Guangzhou Medical University, Guangzhou, China; Ultrasonic Department 
      (D-HW), Guangzhou First People's Hospital, Guangzhou Medical University, 
      Guangzhou, China; and State Key Laboratory of Organ Failure Research (D-LX), 
      Department of Cardiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Li, Shaonan
AU  - Li S
FAU - Lei, Xiaoming
AU  - Lei X
FAU - Liu, Zhen
AU  - Liu Z
FAU - Wu, Daihong
AU  - Wu D
FAU - Luo, Yi
AU  - Luo Y
FAU - Xu, Dingli
AU  - Xu D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 06LU7C9H1V (Triiodothyronine)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Diabetes Mellitus, Type 2/*blood/complications/physiopathology
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/*blood/complications/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Triiodothyronine/*blood
EDAT- 2015/07/15 06:00
MHDA- 2015/10/16 06:00
CRDT- 2015/07/13 06:00
PHST- 2015/07/13 06:00 [entrez]
PHST- 2015/07/15 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - S0002-9629(15)41235-2 [pii]
AID - 10.1097/MAJ.0000000000000524 [doi]
PST - ppublish
SO  - Am J Med Sci. 2015 Aug;350(2):87-94. doi: 10.1097/MAJ.0000000000000524.